Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SIGIRR
  • Mouse genes Sigirr
  • Rat genes Sigirr
  • Zfish genes sigirr
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sigirr

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SIGIRR	IPI	UniProtKB:O00206	Human	PMID:12925853
Molecular Function	GO:0005515	protein binding	SIGIRR	IPI	UniProtKB:O60602	Human	PMID:12925853
Molecular Function	GO:0005515	protein binding	SIGIRR	IPI	UniProtKB:P14778	Human	PMID:12925853
Molecular Function	GO:0005515	protein binding	SIGIRR	IPI	UniProtKB:P51617	Human	PMID:12925853
Molecular Function	GO:0005515	protein binding	SIGIRR	IPI	UniProtKB:Q9NR96	Human	PMID:12925853
Molecular Function	GO:0005515	protein binding	SIGIRR	IPI	UniProtKB:Q9Y4K3	Human	PMID:12925853
Molecular Function	GO:0005515	protein binding	SIGIRR	IPI	UniProtKB:A6NDB9	Human	PMID:21187075
Molecular Function	GO:0005515	protein binding	sigirr	IPI	ZFIN:ZDB-GENE-040219-2	Zfish	PMID:27206770
Molecular Function	GO:0005515	protein binding	sigirr	IPI	ZFIN:ZDB-GENE-040219-3	Zfish	PMID:27206770
Cellular Component	GO:0009986	cell surface	sigirr	IDA		Zfish	PMID:27206770
Cellular Component	GO:0016020	membrane	SIGIRR	IMP		Human	PMID:10346978
Biological Process	GO:0006953	acute-phase response	Sigirr	IMP		Mouse	MGI:MGI:2673012|PMID:12925853
Biological Process	GO:0032682	negative regulation of chemokine production	Sigirr	IMP		Mouse	MGI:MGI:2673012|PMID:12925853
Biological Process	GO:0001960	negative regulation of cytokine-mediated signaling pathway	Sigirr	IMP		Mouse	MGI:MGI:2673012|PMID:12925853
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	SIGIRR	IMP		Human	PMID:12925853
Biological Process	GO:0050728	negative regulation of inflammatory response	sigirr	IMP		Zfish	PMID:27206770

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern