Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SH2D1B
  • Mouse genes Sh2d1b1
  • Rat genes Sh2d1b
  • Zfish genes si:ch73-264p11.1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Sh2d1b1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001784	phosphotyrosine residue binding	Sh2d1b1	IDA		Mouse	PMID:9000139
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:Q9UIB8	Human	PMID:12928397
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:Q96DU3	Human	PMID:16920955
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:Q9UIB8	Human	PMID:23322602
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:Q96DU3	Human	PMID:23346089
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:Q9BZW8	Human	PMID:23346089
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:P16885	Human	PMID:24642916
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:P19174	Human	PMID:24642916
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:Q9BZW8	Human	PMID:24642916
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:P08581	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:P10275	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:P10721	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:Q13480	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:Q9BYV2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:Q53HF2	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:Q8TAK6	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:O15481	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:O95994	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:P51451	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:Q07912-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:Q6FHY5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:Q8NI38	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:Q96D03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:Q99081-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:Q9BYV2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:P01100	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	SH2D1B	IPI	UniProtKB:P12931	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Sh2d1b1	IPI	UniProtKB:Q8BHK6	Mouse	MGI:MGI:3836377|PMID:19151721
Molecular Function	GO:0005515	protein binding	Sh2d1b1	IPI	PR:P08103	Mouse	PMID:16425036
Molecular Function	GO:0005515	protein binding	Sh2d1b1	IPI	PR:P39688	Mouse	PMID:16425036
Molecular Function	GO:0005515	protein binding	Sh2d1b1	IPI	PR:Q9QUM4	Mouse	PMID:16425036
Molecular Function	GO:0005515	protein binding	Sh2d1b1	IPI	PR:P06240	Mouse	PMID:16425036
Molecular Function	GO:0005515	protein binding	Sh2d1b1	IPI	PR:Q07763	Mouse	PMID:16127454
Molecular Function	GO:0005515	protein binding	Sh2d1b1	IPI	PR:P25911	Mouse	PMID:16425036
Molecular Function	GO:0005515	protein binding	Sh2d1b1	IPI	PR:P14234	Mouse	PMID:16425036
Biological Process	GO:0002366	leukocyte activation involved in immune response	Sh2d1b1	IDA		Mouse	MGI:MGI:5448521|PMID:21149608
Biological Process	GO:0002769	natural killer cell inhibitory signaling pathway	Sh2d1b1	IMP	MGI:MGI:3641174	Mouse	PMID:16127454
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	Sh2d1b1	IGI	MGI:MGI:3622649	Mouse	PMID:19648922
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	Sh2d1b1	IMP	MGI:MGI:3641174	Mouse	PMID:16127454
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	Sh2d1b1	IGI	MGI:MGI:1328352	Mouse	PMID:19648922
Biological Process	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	Sh2d1b1	IMP	MGI:MGI:3641174	Mouse	PMID:16127454
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	Sh2d1b1	IMP	MGI:MGI:3641174	Mouse	PMID:16127454
Biological Process	GO:0032689	negative regulation of type II interferon production	Sh2d1b1	IMP	MGI:MGI:3641174	Mouse	PMID:16127454
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Sh2d1b1	IDA		Mouse	PMID:16425036
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Sh2d1b1	IMP	MGI:MGI:3641174	Mouse	PMID:16127454
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Sh2d1b1	IDA		Mouse	PMID:16127454
Biological Process	GO:0045089	positive regulation of innate immune response	Sh2d1b1	IDA		Mouse	MGI:MGI:5448521|PMID:21149608
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	Sh2d1b1	IGI	MGI:MGI:3622649	Mouse	PMID:20962259
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	Sh2d1b1	IGI	MGI:MGI:98923	Mouse	PMID:20962259
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	Sh2d1b1	IGI	MGI:MGI:3622649	Mouse	PMID:19648922
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	Sh2d1b1	IGI	MGI:MGI:1328352	Mouse	PMID:19648922
Biological Process	GO:0002717	positive regulation of natural killer cell mediated immunity	Sh2d1b1	IMP		Mouse	MGI:MGI:4839659|PMID:20962259
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Sh2d1b1	IDA		Mouse	PMID:16425036
Biological Process	GO:0032609	type II interferon production	Sh2d1b1	IMP	MGI:MGI:3641174	Mouse	PMID:16127454

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern