Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SETDB1
  • Mouse genes Setdb1
  • Rat genes Setdb1
  • Zfish genes setdb1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Setdb1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	SETDB1	IDA		Human	PMID:27029610
Molecular Function	GO:0003682	chromatin binding	Setdb1	IDA		Mouse	PMID:22079090
Molecular Function	GO:0003677	DNA binding	Setdb1	IDA		Mouse	PMID:22495301
Molecular Function	GO:0046974	histone H3K9 methyltransferase activity	SETDB1	IDA		Human	PMID:14536086
Molecular Function	GO:0046974	histone H3K9 methyltransferase activity	Setdb1	IDA		Mouse	MGI:MGI:3688032|PMID:11791185
Molecular Function	GO:0046974	histone H3K9 methyltransferase activity	Setdb1	IDA		Mouse	MGI:MGI:6274969|PMID:22939622
Molecular Function	GO:0046974	histone H3K9 methyltransferase activity	Setdb1	IMP		Mouse	PMID:22079090
Molecular Function	GO:0140949	histone H3K9 trimethyltransferase activity	SETDB1	IDA		Human	PMID:14536086
Molecular Function	GO:1990841	promoter-specific chromatin binding	SETDB1	IDA		Human	PMID:24623306
Molecular Function	GO:1990841	promoter-specific chromatin binding	Setdb1	IDA		Mouse	MGI:MGI:5440670|PMID:20164836
Molecular Function	GO:0005515	protein binding	SETDB1	IPI	UniProtKB:Q9Y6K1	Human	PMID:16682412
Molecular Function	GO:0005515	protein binding	SETDB1	IPI	UniProtKB:P31749	Human	PMID:17577629
Molecular Function	GO:0005515	protein binding	SETDB1	IPI	UniProtKB:Q99549	Human	PMID:20871592
Molecular Function	GO:0005515	protein binding	SETDB1	IPI	UniProtKB:Q96GC6	Human	PMID:21170338
Molecular Function	GO:0005515	protein binding	SETDB1	IPI	UniProtKB:Q99549	Human	PMID:26022416
Molecular Function	GO:0005515	protein binding	SETDB1	IPI	UniProtKB:P46100	Human	PMID:27029610
Molecular Function	GO:0005515	protein binding	SETDB1	IPI	UniProtKB:Q6VMQ6	Human	PMID:27732843
Molecular Function	GO:0005515	protein binding	SETDB1	IPI	UniProtKB:Q6P1J9	Human	PMID:29774127
Molecular Function	GO:0005515	protein binding	SETDB1	IPI	UniProtKB:O14978	Human	PMID:32051553
Molecular Function	GO:0005515	protein binding	Setdb1	IPI	UniProtKB:Q5DTW7	Mouse	MGI:MGI:6271895|PMID:29728365
Molecular Function	GO:0005515	protein binding	Setdb1	IPI	UniProtKB:P81270	Mouse	MGI:MGI:3688032|PMID:11791185
Molecular Function	GO:0005515	protein binding	Setdb1	IPI	UniProtKB:E9Q5K9	Mouse	MGI:MGI:6710177|PMID:33658714
Cellular Component	GO:0005737	cytoplasm	SETDB1	IMP		Human	PMID:27732843
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	SETDB1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SETDB1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	SETDB1	IMP		Human	PMID:27732843
Cellular Component	GO:0005634	nucleus	Setdb1	IDA		Mouse	PMID:14993285
Biological Process	GO:0060348	bone development	Setdb1	IMP		Mouse	PMID:22876197
Biological Process	GO:0001833	inner cell mass cell proliferation	Setdb1	IMP	MGI:MGI:3040431	Mouse	PMID:14993285
Biological Process	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	Setdb1	IMP		Mouse	MGI:MGI:5440670|PMID:20164836
Biological Process	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	Setdb1	IMP		Mouse	MGI:MGI:6271895|PMID:29728365
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Setdb1	IMP		Mouse	PMID:22079090
Biological Process	GO:0090309	positive regulation of DNA methylation-dependent heterochromatin formation	SETDB1	IMP		Human	PMID:24623306
Biological Process	GO:0090309	positive regulation of DNA methylation-dependent heterochromatin formation	SETDB1	IMP		Human	PMID:27732843
Biological Process	GO:0090309	positive regulation of DNA methylation-dependent heterochromatin formation	Setdb1	IMP		Mouse	MGI:MGI:5440670|PMID:20164836
Biological Process	GO:0090309	positive regulation of DNA methylation-dependent heterochromatin formation	Setdb1	IMP		Mouse	MGI:MGI:6271895|PMID:29728365
Biological Process	GO:0045471	response to ethanol	Setdb1	IEP		Rat	PMID:23413810|RGD:9491848
Biological Process	GO:0033273	response to vitamin	Setdb1	IEP		Rat	PMID:23413810|RGD:9491848

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern