Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SCYL2
  • Mouse genes Scyl2
  • Rat genes Scyl2
  • Zfish genes scyl2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scyl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SCYL2	IPI	UniProtKB:O14640	Human	PMID:19643732
Molecular Function	GO:0005515	protein binding	SCYL2	IPI	UniProtKB:Q13467	Human	PMID:19643732
Molecular Function	GO:0005515	protein binding	Scyl2	IPI	UniProtKB:O14640	Mouse	MGI:MGI:4943651|PMID:19643732
Molecular Function	GO:0005102	signaling receptor binding	SCYL2	IPI	UniProtKB:Q13467	Human	PMID:19643732
Biological Process	GO:0007420	brain development	Scyl2	IDA		Mouse	MGI:MGI:5694521|PMID:26203146
Biological Process	GO:0008333	endosome to lysosome transport	SCYL2	IDA		Human	PMID:19643732
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway	SCYL2	IDA		Human	PMID:19643732
Biological Process	GO:2000370	positive regulation of clathrin-dependent endocytosis	SCYL2	IDA		Human	PMID:19643732
Biological Process	GO:0002092	positive regulation of receptor internalization	SCYL2	IDA		Human	PMID:19643732
Biological Process	GO:0021860	pyramidal neuron development	Scyl2	IMP		Mouse	MGI:MGI:5694521|PMID:26203146
Biological Process	GO:2000286	receptor internalization involved in canonical Wnt signaling pathway	SCYL2	IDA		Human	PMID:19643732

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern