Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SCUBE2
  • Mouse genes Scube2
  • Rat genes Scube2
  • Zfish genes scube2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scube2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0097108	hedgehog family protein binding	Scube2	IPI	PR:P97812	Mouse	PMID:25639508
Molecular Function	GO:0005515	protein binding	SCUBE2	IPI	UniProtKB:Q8IWY4	Human	PMID:12270931
Molecular Function	GO:0005515	protein binding	Scube2	IPI	PR:Q61115	Mouse	PMID:25639508
Cellular Component	GO:0009986	cell surface	scube2	IDA		Zfish	PMID:15753045
Cellular Component	GO:0005576	extracellular region	scube2	IDA		Zfish	PMID:16626681
Cellular Component	GO:0005615	extracellular space	Scube2	IDA		Mouse	PMID:25639508
Cellular Component	GO:0030141	secretory granule	scube2	IDA		Zfish	PMID:15753045
Biological Process	GO:0008015	blood circulation	scube2	IMP	ZFIN:ZDB-GENO-070808-35	Zfish	PMID:9007249
Biological Process	GO:0008015	blood circulation	scube2	IMP	ZFIN:ZDB-GENO-070808-24	Zfish	PMID:9007249
Biological Process	GO:0008015	blood circulation	scube2	IMP	ZFIN:ZDB-GENO-070808-38	Zfish	PMID:9007249
Biological Process	GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis	Scube2	IMP	MGI:MGI:5698367	Mouse	PMID:25639508
Biological Process	GO:0055001	muscle cell development	scube2	IGI	ZFIN:ZDB-MRPHLNO-050510-1,ZFIN:ZDB-MRPHLNO-140114-6,ZFIN:ZDB-MRPHLNO-140114-7	Zfish	PMID:24131633
Biological Process	GO:0055001	muscle cell development	scube2	IGI	ZFIN:ZDB-MRPHLNO-050510-1,ZFIN:ZDB-MRPHLNO-120813-6,ZFIN:ZDB-MRPHLNO-120813-7	Zfish	PMID:22609552
Biological Process	GO:0042694	muscle cell fate specification	scube2	IMP	ZFIN:ZDB-GENO-980202-1517	Zfish	PMID:10642786
Biological Process	GO:0007517	muscle organ development	scube2	IMP	ZFIN:ZDB-GENO-980202-1517	Zfish	PMID:15660164
Biological Process	GO:0030514	negative regulation of BMP signaling pathway	scube2	IGI		Zfish	PMID:15753045
Biological Process	GO:1902732	positive regulation of chondrocyte proliferation	Scube2	IMP	MGI:MGI:5698367	Mouse	PMID:25639508
Biological Process	GO:0045778	positive regulation of ossification	Scube2	IMP	MGI:MGI:5698367	Mouse	PMID:25639508
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Scube2	IGI	MGI:MGI:96533	Mouse	PMID:25639508
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Scube2	IMP		Mouse	PMID:25639508
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Scube2	IMP	MGI:MGI:5698367	Mouse	PMID:25639508
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	Scube2	IDA		Mouse	PMID:25639508
Biological Process	GO:0045880	positive regulation of smoothened signaling pathway	Scube2	IDA		Mouse	PMID:25639508
Biological Process	GO:0007224	smoothened signaling pathway	scube2	IGI	ZFIN:ZDB-MRPHLNO-050510-1,ZFIN:ZDB-MRPHLNO-120813-6,ZFIN:ZDB-MRPHLNO-120813-7	Zfish	PMID:22609552
Biological Process	GO:0007224	smoothened signaling pathway	scube2	IMP	ZFIN:ZDB-GENO-980202-1517	Zfish	PMID:16626681
Biological Process	GO:0007224	smoothened signaling pathway	scube2	IMP	ZFIN:ZDB-GENO-980202-1517	Zfish	PMID:15660164
Biological Process	GO:0007224	smoothened signaling pathway	scube2	IGI	ZFIN:ZDB-GENO-050209-30,ZFIN:ZDB-GENO-980202-1517	Zfish	PMID:16626681
Biological Process	GO:0007224	smoothened signaling pathway	scube2	IGI	ZFIN:ZDB-GENE-980526-166,ZFIN:ZDB-MRPHLNO-050510-1,ZFIN:ZDB-MRPHLNO-120813-6,ZFIN:ZDB-MRPHLNO-120813-7	Zfish	PMID:22609552
Biological Process	GO:0001756	somitogenesis	scube2	IMP	ZFIN:ZDB-GENO-980202-1517	Zfish	PMID:16626681
Biological Process	GO:0001756	somitogenesis	scube2	IMP	ZFIN:ZDB-GENO-980202-1089,ZFIN:ZDB-GENO-980202-1517	Zfish	PMID:16626681
Biological Process	GO:0001756	somitogenesis	scube2	IMP	ZFIN:ZDB-GENO-980202-1089	Zfish	PMID:16626681
Biological Process	GO:0051146	striated muscle cell differentiation	scube2	IMP	ZFIN:ZDB-GENO-980202-1517	Zfish	PMID:16626681

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern