Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SCN4B
  • Mouse genes Scn4b
  • Rat genes Scn4b
  • Zfish genes scn4ba,scn4bb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scn4b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	SCN4B	IPI	UniProtKB:O95070	Human	PMID:32296183
Molecular Function	GO:0017080	sodium channel regulator activity	SCN4B	IDA		Human	PMID:17592081
Molecular Function	GO:0017080	sodium channel regulator activity	SCN4B	IDA		Human	PMID:24297919
Molecular Function	GO:0044325	transmembrane transporter binding	SCN4B	IPI	UniProtKB:Q14524	Human	PMID:17592081
Molecular Function	GO:0005248	voltage-gated sodium channel activity	SCN4B	IDA		Human	PMID:12930796
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn4b	IDA		Mouse	PMID:20566860
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn4b	IMP		Mouse	PMID:20566860
Molecular Function	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential	SCN4B	IMP		Human	PMID:17592081
Cellular Component	GO:0014704	intercalated disc	Scn4b	IDA		Mouse	MGI:MGI:3763979|PMID:17884088
Cellular Component	GO:0005886	plasma membrane	SCN4B	IDA		Human	PMID:24297919
Cellular Component	GO:0005886	plasma membrane	Scn4b	IDA		Rat	PMID:19426735|RGD:2317326
Cellular Component	GO:0001518	voltage-gated sodium channel complex	SCN4B	IDA		Human	PMID:12930796
Cellular Component	GO:0001518	voltage-gated sodium channel complex	SCN4B	IDA		Human	PMID:17592081
Cellular Component	GO:0001518	voltage-gated sodium channel complex	SCN4B	IMP		Human	PMID:24297919
Biological Process	GO:0086016	AV node cell action potential	SCN4B	IMP		Human	PMID:17592081
Biological Process	GO:0086002	cardiac muscle cell action potential involved in contraction	SCN4B	IMP		Human	PMID:17592081
Biological Process	GO:0060048	cardiac muscle contraction	SCN4B	IMP		Human	PMID:17592081
Biological Process	GO:0051649	establishment of localization in cell	Scn4b	IMP		Mouse	PMID:20566860
Biological Process	GO:0051649	establishment of localization in cell	Scn4b	IDA		Mouse	PMID:20566860
Biological Process	GO:0086012	membrane depolarization during cardiac muscle cell action potential	SCN4B	IMP		Human	PMID:17592081
Biological Process	GO:0010765	positive regulation of sodium ion transport	SCN4B	IDA		Human	PMID:17592081
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	SCN4B	IMP		Human	PMID:17592081
Biological Process	GO:2000649	regulation of sodium ion transmembrane transporter activity	SCN4B	IDA		Human	PMID:17592081
Biological Process	GO:2000649	regulation of sodium ion transmembrane transporter activity	SCN4B	IDA		Human	PMID:24297919
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	SCN4B	IMP		Human	PMID:17592081
Biological Process	GO:0035725	sodium ion transmembrane transport	SCN4B	IDA		Human	PMID:20226894
Biological Process	GO:0035725	sodium ion transmembrane transport	Scn4b	IMP		Mouse	PMID:20566860
Biological Process	GO:0035725	sodium ion transmembrane transport	Scn4b	IDA		Mouse	PMID:20566860
Biological Process	GO:0006814	sodium ion transport	SCN4B	IDA		Human	PMID:12930796

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern