Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes SCN1A
  • Mouse genes Scn1a
  • Rat genes Scn1a
  • Zfish genes scn1laa,scn1lab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scn1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0031402	sodium ion binding	Scn1a	IDA		Rat	PMID:15664695|RGD:1599536
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	SCN1A	IDA		Human	PMID:22150645
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	SCN1A	IMP		Human	PMID:22150645
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn1a	IDA		Mouse	MGI:MGI:5796061|PMID:27281198
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn1a	IMP	MGI:MGI:3665322	Mouse	PMID:16921370
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn1a	IDA		Rat	PMID:15664695|RGD:1599536
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn1a	IMP		Rat	PMID:17273863|RGD:2289022
Molecular Function	GO:0005248	voltage-gated sodium channel activity	scn1laa	IMP	ZFIN:ZDB-MRPHLNO-050816-1	Zfish	PMID:15673553
Cellular Component	GO:0030424	axon	Scn1a	IDA		Mouse	PMID:17928448
Cellular Component	GO:0030424	axon	Scn1a	IDA		Mouse	PMID:17537961
Cellular Component	GO:0043194	axon initial segment	Scn1a	IDA		Mouse	PMID:17537961
Cellular Component	GO:0014704	intercalated disc	Scn1a	IDA		Mouse	PMID:15746173
Cellular Component	GO:0016020	membrane	Scn1a	IDA		Mouse	PMID:17537961
Cellular Component	GO:0016020	membrane	Scn1a	IDA		Mouse	PMID:10827969
Cellular Component	GO:0043025	neuronal cell body	Scn1a	IDA		Mouse	PMID:17928448
Cellular Component	GO:0043025	neuronal cell body	Scn1a	IDA		Mouse	PMID:17537961
Cellular Component	GO:0033268	node of Ranvier	Scn1a	IDA		Mouse	PMID:17537961
Cellular Component	GO:0016604	nuclear body	SCN1A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	SCN1A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	SCN1A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Scn1a	IDA		Rat	PMID:17273863|RGD:2289022
Cellular Component	GO:0042734	presynaptic membrane	Scn1a	IDA		Rat	PMID:18079688|RGD:13702425
Cellular Component	GO:0034706	sodium channel complex	Scn1a	IPI	PR:Q9JJV9	Mouse	PMID:15272007
Cellular Component	GO:0034706	sodium channel complex	Scn1a	IPI	PR:P97952	Mouse	PMID:15272007
Cellular Component	GO:0034706	sodium channel complex	Scn1a	IPI	UniProtKB:Q9WTU3	Mouse	PMID:15272007
Cellular Component	GO:0030315	T-tubule	Scn1a	IDA		Mouse	PMID:15746173
Cellular Component	GO:0001518	voltage-gated sodium channel complex	Scn1a	IDA		Rat	PMID:15664695|RGD:1599536
Cellular Component	GO:0030018	Z disc	Scn1a	IDA		Mouse	MGI:MGI:3763979|PMID:17884088
Biological Process	GO:0007628	adult walking behavior	Scn1a	IMP	MGI:MGI:3713733	Mouse	PMID:17537961
Biological Process	GO:0007628	adult walking behavior	Scn1a	IMP	MGI:MGI:3665322	Mouse	PMID:17928448
Biological Process	GO:0086002	cardiac muscle cell action potential involved in contraction	SCN1A	IMP		Human	PMID:27207958
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	Scn1a	IDA		Mouse	MGI:MGI:5796061|PMID:27281198
Biological Process	GO:0051649	establishment of localization in cell	Scn1a	IMP	MGI:MGI:3665322	Mouse	PMID:16921370
Biological Process	GO:0051649	establishment of localization in cell	Scn1a	IMP	MGI:MGI:3665322	Mouse	PMID:17928448
Biological Process	GO:0050884	neuromuscular process controlling posture	Scn1a	IMP	MGI:MGI:3665322	Mouse	PMID:16921370
Biological Process	GO:0050884	neuromuscular process controlling posture	Scn1a	IMP	MGI:MGI:3665322	Mouse	PMID:17928448
Biological Process	GO:0019228	neuronal action potential	Scn1a	IMP	MGI:MGI:3665322	Mouse	PMID:17928448
Biological Process	GO:0019228	neuronal action potential	Scn1a	IMP	MGI:MGI:3665322	Mouse	PMID:16921370
Biological Process	GO:0019228	neuronal action potential	Scn1a	IDA		Rat	PMID:15664695|RGD:1599536
Biological Process	GO:0019228	neuronal action potential	Scn1a	IDA		Rat	PMID:15917456|RGD:2289019
Biological Process	GO:0019228	neuronal action potential	Scn1a	IMP		Rat	PMID:17273863|RGD:2289022
Biological Process	GO:0019228	neuronal action potential	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:24002024
Biological Process	GO:0019227	neuronal action potential propagation	Scn1a	IMP	MGI:MGI:3713733	Mouse	PMID:17322896
Biological Process	GO:0042752	regulation of circadian rhythm	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:28812061
Biological Process	GO:0006110	regulation of glycolytic process	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:27066534
Biological Process	GO:1904059	regulation of locomotor rhythm	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:28812061
Biological Process	GO:0042391	regulation of membrane potential	Scn1a	IMP	MGI:MGI:3665322	Mouse	PMID:17928448
Biological Process	GO:0002082	regulation of oxidative phosphorylation	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:27066534
Biological Process	GO:0006814	sodium ion transport	Scn1a	IDA		Mouse	MGI:MGI:5796061|PMID:27281198
Biological Process	GO:0006814	sodium ion transport	Scn1a	IMP	MGI:MGI:3665322	Mouse	PMID:16921370
Biological Process	GO:0006814	sodium ion transport	Scn1a	IMP	MGI:MGI:3665322	Mouse	PMID:17928448
Biological Process	GO:0036269	swimming behavior	scn1lab	IMP	ZFIN:ZDB-GENO-120910-12	Zfish	PMID:24002024
Biological Process	GO:0099536	synaptic signaling	scn1lab	IMP	ZFIN:ZDB-GENO-161012-2	Zfish	PMID:27305978

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern