Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Scn10a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes SCN10A
- Mouse genes Scn10a
- Rat genes Scn10a
- Zfish genes scn12aa,scn5lab
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Scn10a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	Scn10a	IPI	UniProtKB:P05943	Rat	PMID:12050667\|RGD:8554600
Molecular Function	GO:0005515	protein binding	Scn10a	IPI	UniProtKB:P05943	Rat	PMID:12591166\|RGD:8553968
Molecular Function	GO:0005515	protein binding	Scn10a	IPI	UniProtKB:Q63425	Rat	PMID:12591166\|RGD:8553968
Molecular Function	GO:0005515	protein binding	Scn10a	IPI	UniProtKB:Q9QZR8	Rat	PMID:12591166\|RGD:8553968
Molecular Function	GO:0005515	protein binding	Scn10a	IPI	UniProtKB:Q9Z336	Rat	PMID:12591166\|RGD:8553968
Molecular Function	GO:0005515	protein binding	Scn10a	IPI	RGD:628721	Rat	PMID:15797711\|RGD:1359053
Molecular Function	GO:0044325	transmembrane transporter binding	SCN10A	IPI	UniProtKB:Q14524	Human	PMID:24998131
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Scn10a	IDA		Rat	PMID:26187311\|RGD:155230761
Molecular Function	GO:0099508	voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Scn10a	IMP		Rat	PMID:26187311\|RGD:155230761
Molecular Function	GO:0005248	voltage-gated sodium channel activity	SCN10A	IDA		Human	PMID:9839820
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn10a	IDA		Mouse	PMID:16029194
Molecular Function	GO:0005248	voltage-gated sodium channel activity	Scn10a	IDA		Rat	PMID:8538791\|RGD:69979
Molecular Function	GO:0005248	voltage-gated sodium channel activity	scn5lab	IDA		Zfish	PMID:17623065
Cellular Component	GO:0030424	axon	Scn10a	IDA		Mouse	PMID:16029194
Cellular Component	GO:0030424	axon	Scn10a	IDA		Rat	PMID:21118538\|RGD:15090835
Cellular Component	GO:0044299	C-fiber	Scn10a	IDA		Mouse	PMID:16029194
Cellular Component	GO:0071439	clathrin complex	Scn10a	IDA		Rat	PMID:15797711\|RGD:1359053
Cellular Component	GO:0070062	extracellular exosome	SCN10A	HDA		Human	PMID:19056867
Cellular Component	GO:0098978	glutamatergic synapse	Scn10a	IDA		Rat	PMID:19162133\|RGD:13702365
Cellular Component	GO:0016020	membrane	Scn10a	IDA		Rat	PMID:8538791\|RGD:69979
Cellular Component	GO:0005886	plasma membrane	Scn10a	IDA		Mouse	PMID:16029194
Cellular Component	GO:0042734	presynaptic membrane	Scn10a	IDA		Rat	PMID:19162133\|RGD:13702365
Cellular Component	GO:0001518	voltage-gated sodium channel complex	SCN10A	IDA		Human	PMID:9839820
Biological Process	GO:0086016	AV node cell action potential	SCN10A	IMP		Human	PMID:24998131
Biological Process	GO:0048266	behavioral response to pain	Scn10a	IMP	MGI:MGI:2180183	Mouse	PMID:24440715
Biological Process	GO:0086043	bundle of His cell action potential	SCN10A	IMP		Human	PMID:24998131
Biological Process	GO:0061337	cardiac conduction	Scn10a	IMP	MGI:MGI:2180183	Mouse	PMID:20062061
Biological Process	GO:0007623	circadian rhythm	Scn10a	IMP	MGI:MGI:2180183	Mouse	PMID:25101983
Biological Process	GO:0050974	detection of mechanical stimulus involved in sensory perception	Scn10a	IMP	MGI:MGI:2180183	Mouse	PMID:25101983
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	Scn10a	IMP	MGI:MGI:4430300	Mouse	PMID:19931571
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	Scn10a	IMP	MGI:MGI:2180183	Mouse	PMID:25101983
Biological Process	GO:0051649	establishment of localization in cell	Scn10a	IDA		Mouse	PMID:16029194
Biological Process	GO:0001947	heart looping	scn12aa	IMP	ZFIN:ZDB-MRPHLNO-100616-2	Zfish	PMID:20339120
Biological Process	GO:0001947	heart looping	scn12aa	IMP	ZFIN:ZDB-MRPHLNO-100616-1	Zfish	PMID:20339120
Biological Process	GO:0001947	heart looping	scn12aa	IGI	ZFIN:ZDB-MRPHLNO-100616-1,ZFIN:ZDB-MRPHLNO-100616-3	Zfish	PMID:20339120
Biological Process	GO:0001947	heart looping	scn12aa	IGI	ZFIN:ZDB-MRPHLNO-100616-1,ZFIN:ZDB-MRPHLNO-120105-1	Zfish	PMID:20339120
Biological Process	GO:0001947	heart looping	scn5lab	IGI	ZFIN:ZDB-MRPHLNO-100616-1,ZFIN:ZDB-MRPHLNO-100616-3	Zfish	PMID:20339120
Biological Process	GO:0001947	heart looping	scn5lab	IGI	ZFIN:ZDB-MRPHLNO-100616-1,ZFIN:ZDB-MRPHLNO-120105-1	Zfish	PMID:20339120
Biological Process	GO:0001947	heart looping	scn5lab	IMP	ZFIN:ZDB-MRPHLNO-100616-3	Zfish	PMID:20339120
Biological Process	GO:0001947	heart looping	scn5lab	IMP	ZFIN:ZDB-MRPHLNO-120105-1	Zfish	PMID:20339120
Biological Process	GO:0003007	heart morphogenesis	scn12aa	IMP	ZFIN:ZDB-MRPHLNO-100616-1	Zfish	PMID:20339120
Biological Process	GO:0003007	heart morphogenesis	scn12aa	IGI	ZFIN:ZDB-MRPHLNO-100616-1,ZFIN:ZDB-MRPHLNO-120105-1	Zfish	PMID:20339120
Biological Process	GO:0003007	heart morphogenesis	scn12aa	IGI	ZFIN:ZDB-MRPHLNO-100616-1,ZFIN:ZDB-MRPHLNO-100616-3	Zfish	PMID:20339120
Biological Process	GO:0003007	heart morphogenesis	scn12aa	IMP	ZFIN:ZDB-MRPHLNO-100616-2	Zfish	PMID:20339120
Biological Process	GO:0003007	heart morphogenesis	scn5lab	IGI	ZFIN:ZDB-MRPHLNO-100616-1,ZFIN:ZDB-MRPHLNO-100616-3	Zfish	PMID:20339120
Biological Process	GO:0003007	heart morphogenesis	scn5lab	IMP	ZFIN:ZDB-MRPHLNO-100616-3	Zfish	PMID:20339120
Biological Process	GO:0003007	heart morphogenesis	scn5lab	IGI	ZFIN:ZDB-MRPHLNO-100616-1,ZFIN:ZDB-MRPHLNO-120105-1	Zfish	PMID:20339120
Biological Process	GO:0003007	heart morphogenesis	scn5lab	IMP	ZFIN:ZDB-MRPHLNO-120105-1	Zfish	PMID:20339120
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	Scn10a	IEP		Rat	PMID:21640979\|RGD:6484223
Biological Process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	SCN10A	IMP		Human	PMID:20062061
Biological Process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	SCN10A	IMP		Human	PMID:21041692
Biological Process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	Scn10a	IMP	MGI:MGI:2180183	Mouse	PMID:20062061
Biological Process	GO:0055117	regulation of cardiac muscle contraction	SCN10A	IMP		Human	PMID:20062061
Biological Process	GO:0008016	regulation of heart contraction	scn12aa	IMP	ZFIN:ZDB-MRPHLNO-100616-1,ZFIN:ZDB-MRPHLNO-100616-3	Zfish	PMID:25282101
Biological Process	GO:0008016	regulation of heart contraction	scn12aa	IMP	ZFIN:ZDB-MRPHLNO-100616-2	Zfish	PMID:20339120
Biological Process	GO:0008016	regulation of heart contraction	scn12aa	IGI	ZFIN:ZDB-MRPHLNO-100616-1,ZFIN:ZDB-MRPHLNO-100616-3	Zfish	PMID:20339120
Biological Process	GO:0008016	regulation of heart contraction	scn12aa	IGI	ZFIN:ZDB-MRPHLNO-100616-1,ZFIN:ZDB-MRPHLNO-120105-1	Zfish	PMID:20339120
Biological Process	GO:0008016	regulation of heart contraction	scn12aa	IMP	ZFIN:ZDB-MRPHLNO-100616-1	Zfish	PMID:20339120
Biological Process	GO:0008016	regulation of heart contraction	scn5lab	IMP	ZFIN:ZDB-MRPHLNO-100616-1,ZFIN:ZDB-MRPHLNO-100616-3	Zfish	PMID:25282101
Biological Process	GO:0008016	regulation of heart contraction	scn5lab	IGI	ZFIN:ZDB-MRPHLNO-100616-1,ZFIN:ZDB-MRPHLNO-120105-1	Zfish	PMID:20339120
Biological Process	GO:0008016	regulation of heart contraction	scn5lab	IMP	ZFIN:ZDB-MRPHLNO-100616-3	Zfish	PMID:20339120
Biological Process	GO:0008016	regulation of heart contraction	scn5lab	IMP	ZFIN:ZDB-MRPHLNO-120105-1	Zfish	PMID:20339120
Biological Process	GO:0008016	regulation of heart contraction	scn5lab	IGI	ZFIN:ZDB-MRPHLNO-100616-1,ZFIN:ZDB-MRPHLNO-100616-3	Zfish	PMID:20339120
Biological Process	GO:0002027	regulation of heart rate	SCN10A	IMP		Human	PMID:20062061
Biological Process	GO:0002027	regulation of heart rate	SCN10A	IMP		Human	PMID:21041692
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	SCN10A	IDA		Human	PMID:9839820
Biological Process	GO:0019233	sensory perception of pain	Scn10a	IMP		Rat	PMID:21965668\|RGD:6484251
Biological Process	GO:0035725	sodium ion transmembrane transport	SCN10A	IDA		Human	PMID:9839820
Biological Process	GO:0006814	sodium ion transport	Scn10a	IDA		Mouse	PMID:16029194
Biological Process	GO:0006814	sodium ion transport	Scn10a	IDA		Rat	PMID:8538791\|RGD:69979

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.