Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RYR3
  • Mouse genes Ryr3
  • Rat genes Ryr3
  • Zfish genes ryr3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ryr3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048763	calcium-induced calcium release activity	Ryr3	IDA		Rat	PMID:18799678|RGD:7175259
Molecular Function	GO:0015278	calcium-release channel activity	RYR3	IMP		Human	PMID:9395096
Molecular Function	GO:0005515	protein binding	ryr3	IPI	ZFIN:ZDB-GENE-040801-248	Zfish	PMID:23736855
Molecular Function	GO:0005219	ryanodine-sensitive calcium-release channel activity	Ryr3	IDA		Rat	PMID:18799678|RGD:7175259
Cellular Component	GO:0005783	endoplasmic reticulum	Ryr3	IDA		Rat	PMID:18799678|RGD:7175259
Cellular Component	GO:0030314	junctional membrane complex	Ryr3	IDA		Mouse	PMID:10444070
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Ryr3	IDA		Rat	PMID:20177054|RGD:7242274
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	Ryr3	IDA		Mouse	PMID:14592808
Biological Process	GO:0006816	calcium ion transport	RYR3	IMP		Human	PMID:9395096
Biological Process	GO:1990791	dorsal root ganglion development	ryr3	IGI	ZFIN:ZDB-GENE-020108-2	Zfish	PMID:29754802
Biological Process	GO:1990791	dorsal root ganglion development	ryr3	IMP	ZFIN:ZDB-MRPHLNO-090108-5,ZFIN:ZDB-MRPHLNO-090109-2	Zfish	PMID:29754802
Biological Process	GO:0048484	enteric nervous system development	ryr3	IMP	ZFIN:ZDB-MRPHLNO-090108-5,ZFIN:ZDB-MRPHLNO-090109-2	Zfish	PMID:29754802
Biological Process	GO:0048484	enteric nervous system development	ryr3	IGI	ZFIN:ZDB-GENE-020108-2	Zfish	PMID:29754802
Biological Process	GO:0006874	intracellular calcium ion homeostasis	Ryr3	IMP	MGI:MGI:2181794	Mouse	PMID:9384575
Biological Process	GO:0051481	negative regulation of cytosolic calcium ion concentration	Ryr3	IDA		Rat	PMID:18799678|RGD:7175259
Biological Process	GO:0021532	neural tube patterning	ryr3	IGI	ZFIN:ZDB-GENE-071001-1,ZFIN:ZDB-GENE-020108-2	Zfish	PMID:29754802
Biological Process	GO:0021532	neural tube patterning	ryr3	IMP	ZFIN:ZDB-GENO-190227-9	Zfish	PMID:29754802
Biological Process	GO:0048741	skeletal muscle fiber development	ryr3	IMP	ZFIN:ZDB-GENO-190227-2	Zfish	PMID:29754802
Biological Process	GO:0048741	skeletal muscle fiber development	ryr3	IMP	ZFIN:ZDB-MRPHLNO-090108-5,ZFIN:ZDB-MRPHLNO-090109-2	Zfish	PMID:29754802
Biological Process	GO:0048741	skeletal muscle fiber development	ryr3	IGI	ZFIN:ZDB-GENE-070705-417,ZFIN:ZDB-GENE-020108-2	Zfish	PMID:29754802
Biological Process	GO:0007224	smoothened signaling pathway	ryr3	IGI	ZFIN:ZDB-GENE-020108-2	Zfish	PMID:29754802
Biological Process	GO:0007224	smoothened signaling pathway	ryr3	IGI	ZFIN:ZDB-GENE-070705-417,ZFIN:ZDB-GENE-020108-2	Zfish	PMID:29754802
Biological Process	GO:0007224	smoothened signaling pathway	ryr3	IMP	ZFIN:ZDB-MRPHLNO-090108-5,ZFIN:ZDB-MRPHLNO-090109-2	Zfish	PMID:29754802
Biological Process	GO:0007224	smoothened signaling pathway	ryr3	IGI	ZFIN:ZDB-GENE-071001-1,ZFIN:ZDB-GENE-020108-2	Zfish	PMID:29754802
Biological Process	GO:0007224	smoothened signaling pathway	ryr3	IMP	ZFIN:ZDB-GENO-190227-2	Zfish	PMID:29754802
Biological Process	GO:0007224	smoothened signaling pathway	ryr3	IMP	ZFIN:ZDB-GENO-190227-9	Zfish	PMID:29754802
Biological Process	GO:0006941	striated muscle contraction	Ryr3	IMP	MGI:MGI:2181794	Mouse	PMID:9384575

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern