Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ROBO4
  • Mouse genes Robo4
  • Rat genes
  • Zfish genes robo4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Robo4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	ROBO4	IPI	UniProtKB:Q96LK0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Robo4	IPI	UniProtKB:O43294	Mouse	MGI:MGI:4430779|PMID:19855388
Molecular Function	GO:0005515	protein binding	Robo4	IPI	UniProtKB:O94813	Mouse	PMID:12941633
Molecular Function	GO:0038023	signaling receptor activity	Robo4	IDA		Mouse	PMID:12941633
Cellular Component	GO:0009897	external side of plasma membrane	Robo4	IDA		Mouse	PMID:12941633
Cellular Component	GO:0070062	extracellular exosome	ROBO4	HDA		Human	PMID:23533145
Cellular Component	GO:0005886	plasma membrane	robo4	IDA		Zfish	PMID:16481322
Biological Process	GO:0001525	angiogenesis	ROBO4	IGI	UniProtKB:Q71B05	Human	PMID:15849270
Biological Process	GO:0001525	angiogenesis	robo4	IMP	ZFIN:ZDB-MRPHLNO-050525-1	Zfish	PMID:15849270
Biological Process	GO:0001525	angiogenesis	robo4	IMP	ZFIN:ZDB-MRPHLNO-050525-2	Zfish	PMID:15849270
Biological Process	GO:0001525	angiogenesis	robo4	IMP		Zfish	PMID:15849270
Biological Process	GO:0043534	blood vessel endothelial cell migration	Robo4	IDA		Mouse	PMID:12941633
Biological Process	GO:0043542	endothelial cell migration	robo4	IDA		Zfish	PMID:16481322
Biological Process	GO:0061028	establishment of endothelial barrier	ROBO4	IMP		Human	PMID:30455415
Biological Process	GO:0046847	filopodium assembly	robo4	IDA		Zfish	PMID:16481322
Biological Process	GO:0030032	lamellipodium assembly	robo4	IDA		Zfish	PMID:16481322
Biological Process	GO:0043537	negative regulation of blood vessel endothelial cell migration	Robo4	IDA		Mouse	PMID:12941633
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	robo4	IDA		Zfish	PMID:16481322
Biological Process	GO:0035022	positive regulation of Rac protein signal transduction	robo4	IDA		Zfish	PMID:16481322
Biological Process	GO:0035022	positive regulation of Rac protein signal transduction	robo4	IMP	ZFIN:ZDB-MRPHLNO-050525-1,ZFIN:ZDB-MRPHLNO-050525-2	Zfish	PMID:16481322
Biological Process	GO:0051057	positive regulation of small GTPase mediated signal transduction	robo4	IMP	ZFIN:ZDB-MRPHLNO-050525-1,ZFIN:ZDB-MRPHLNO-050525-2	Zfish	PMID:16481322
Biological Process	GO:0051057	positive regulation of small GTPase mediated signal transduction	robo4	IDA		Zfish	PMID:16481322
Biological Process	GO:0030334	regulation of cell migration	robo4	IMP	ZFIN:ZDB-MRPHLNO-050525-1,ZFIN:ZDB-MRPHLNO-050525-2	Zfish	PMID:16481322

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern