Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RFWD3
  • Mouse genes Rfwd3
  • Rat genes
  • Zfish genes rfwd3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rfwd3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0097371	MDM2/MDM4 family protein binding	RFWD3	IPI	UniProtKB:Q00987	Human	PMID:20173098
Molecular Function	GO:0002039	p53 binding	RFWD3	IPI	UniProtKB:P04637	Human	PMID:20173098
Molecular Function	GO:0005515	protein binding	RFWD3	IPI	UniProtKB:P61088	Human	PMID:19549727
Molecular Function	GO:0005515	protein binding	RFWD3	IPI	UniProtKB:P04637	Human	PMID:20173098
Molecular Function	GO:0005515	protein binding	RFWD3	IPI	UniProtKB:Q00987	Human	PMID:20173098
Molecular Function	GO:0005515	protein binding	RFWD3	IPI	UniProtKB:Q00987-11	Human	PMID:20173098
Molecular Function	GO:0005515	protein binding	RFWD3	IPI	UniProtKB:P15927	Human	PMID:21504906
Molecular Function	GO:0005515	protein binding	RFWD3	IPI	UniProtKB:P15927	Human	PMID:24126761
Molecular Function	GO:0005515	protein binding	RFWD3	IPI	UniProtKB:P61088	Human	PMID:25260751
Molecular Function	GO:0005515	protein binding	RFWD3	IPI	UniProtKB:P15927	Human	PMID:28575657
Molecular Function	GO:0005515	protein binding	RFWD3	IPI	UniProtKB:Q06609	Human	PMID:28575657
Molecular Function	GO:0005515	protein binding	RFWD3	IPI	UniProtKB:P15927	Human	PMID:28575658
Molecular Function	GO:0005515	protein binding	RFWD3	IPI	UniProtKB:P15927	Human	PMID:28691929
Molecular Function	GO:0061630	ubiquitin protein ligase activity	RFWD3	IDA		Human	PMID:20173098
Molecular Function	GO:0061630	ubiquitin protein ligase activity	RFWD3	IDA		Human	PMID:26474068
Molecular Function	GO:0061630	ubiquitin protein ligase activity	RFWD3	IDA		Human	PMID:28575657
Molecular Function	GO:0061630	ubiquitin protein ligase activity	RFWD3	IDA		Human	PMID:28575658
Cellular Component	GO:0005654	nucleoplasm	RFWD3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	RFWD3	IDA		Human	PMID:20173098
Cellular Component	GO:0005634	nucleus	RFWD3	IMP		Human	PMID:28691929
Cellular Component	GO:0090734	site of DNA damage	RFWD3	IDA		Human	PMID:28575657
Cellular Component	GO:0090734	site of DNA damage	RFWD3	IDA		Human	PMID:28575658
Cellular Component	GO:0035861	site of double-strand break	RFWD3	IDA		Human	PMID:21504906
Biological Process	GO:0006974	DNA damage response	RFWD3	IDA		Human	PMID:26474068
Biological Process	GO:0006974	DNA damage response	RFWD3	IDA		Human	PMID:28575657
Biological Process	GO:0006974	DNA damage response	RFWD3	IDA		Human	PMID:28575658
Biological Process	GO:0000724	double-strand break repair via homologous recombination	RFWD3	IDA		Human	PMID:26474068
Biological Process	GO:0000724	double-strand break repair via homologous recombination	RFWD3	IDA		Human	PMID:28575657
Biological Process	GO:0000724	double-strand break repair via homologous recombination	RFWD3	IDA		Human	PMID:28575658
Biological Process	GO:0000724	double-strand break repair via homologous recombination	RFWD3	IMP		Human	PMID:28691929
Biological Process	GO:0036297	interstrand cross-link repair	RFWD3	IMP		Human	PMID:28575657
Biological Process	GO:0036297	interstrand cross-link repair	RFWD3	IMP		Human	PMID:28575658
Biological Process	GO:0031571	mitotic G1 DNA damage checkpoint signaling	RFWD3	IMP		Human	PMID:20173098
Biological Process	GO:0016567	protein ubiquitination	RFWD3	IDA		Human	PMID:20173098
Biological Process	GO:0016567	protein ubiquitination	RFWD3	IDA		Human	PMID:26474068
Biological Process	GO:0016567	protein ubiquitination	RFWD3	IDA		Human	PMID:28575657
Biological Process	GO:0016567	protein ubiquitination	RFWD3	IDA		Human	PMID:28575658
Biological Process	GO:2000001	regulation of DNA damage checkpoint	RFWD3	IMP		Human	PMID:21504906
Biological Process	GO:0031297	replication fork processing	RFWD3	IDA		Human	PMID:26474068
Biological Process	GO:0010212	response to ionizing radiation	RFWD3	IDA		Human	PMID:20173098

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern