Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RECQL4
  • Mouse genes Recql4
  • Rat genes Recql4
  • Zfish genes recql4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Recql4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000405	bubble DNA binding	RECQL4	IDA		Human	PMID:19177149
Molecular Function	GO:1990814	DNA/DNA annealing activity	RECQL4	IDA		Human	PMID:19177149
Molecular Function	GO:0032357	oxidized purine DNA binding	RECQL4	IDA		Human	PMID:22039056
Molecular Function	GO:0005515	protein binding	RECQL4	IPI	UniProtKB:P54274	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	RECQL4	IPI	UniProtKB:P54274	Human	PMID:22039056
Molecular Function	GO:0005515	protein binding	RECQL4	IPI	UniProtKB:Q15554	Human	PMID:22039056
Molecular Function	GO:0061821	telomeric D-loop binding	RECQL4	IDA		Human	PMID:22039056
Cellular Component	GO:0000781	chromosome, telomeric region	RECQL4	IMP		Human	PMID:22039056
Cellular Component	GO:0016020	membrane	RECQL4	HDA		Human	PMID:19946888
Cellular Component	GO:0005654	nucleoplasm	RECQL4	IDA		Human	GO_REF:0000052
Biological Process	GO:0032508	DNA duplex unwinding	RECQL4	IDA		Human	PMID:19177149
Biological Process	GO:0006260	DNA replication	RECQL4	IMP		Human	PMID:22039056
Biological Process	GO:0045875	negative regulation of sister chromatid cohesion	Recql4	IMP	MGI:MGI:3045113	Mouse	PMID:15703196
Biological Process	GO:0043473	pigmentation	Recql4	IMP	MGI:MGI:3045113	Mouse	PMID:15703196
Biological Process	GO:0008284	positive regulation of cell population proliferation	Recql4	IMP		Mouse	PMID:16600186
Biological Process	GO:0007062	sister chromatid cohesion	Recql4	IMP	MGI:MGI:3045113	Mouse	PMID:15703196
Biological Process	GO:0001501	skeletal system development	Recql4	IMP	MGI:MGI:2677314	Mouse	PMID:16600186
Biological Process	GO:0048705	skeletal system morphogenesis	Recql4	IMP	MGI:MGI:3045113	Mouse	PMID:15703196
Biological Process	GO:0000723	telomere maintenance	RECQL4	IMP		Human	PMID:22039056
Biological Process	GO:0061820	telomeric D-loop disassembly	RECQL4	IDA		Human	PMID:22039056
Biological Process	GO:0061820	telomeric D-loop disassembly	RECQL4	IGI	UniProtKB:P54274	Human	PMID:22039056
Biological Process	GO:0061820	telomeric D-loop disassembly	RECQL4	IGI	UniProtKB:Q14191	Human	PMID:22039056
Biological Process	GO:0061820	telomeric D-loop disassembly	RECQL4	IGI	UniProtKB:Q15554	Human	PMID:22039056
Biological Process	GO:0061820	telomeric D-loop disassembly	RECQL4	IGI	UniProtKB:Q9NUX5	Human	PMID:22039056

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern