Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes RAPGEF6
  • Mouse genes Rapgef6
  • Rat genes Rapgef6
  • Zfish genes rapgef6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Rapgef6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030742	GTP-dependent protein binding	RAPGEF6	IDA		Human	PMID:11524421
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	RAPGEF6	IDA		Human	PMID:11524421
Molecular Function	GO:0070300	phosphatidic acid binding	RAPGEF6	IDA		Human	PMID:22797597
Molecular Function	GO:0005515	protein binding	RAPGEF6	IPI	UniProtKB:Q12923	Human	PMID:12095257
Molecular Function	GO:0005515	protein binding	RAPGEF6	IPI	UniProtKB:Q12923	Human	PMID:14698303
Molecular Function	GO:0005515	protein binding	RAPGEF6	IPI	UniProtKB:Q12923	Human	PMID:17240990
Molecular Function	GO:0005515	protein binding	RAPGEF6	IPI	UniProtKB:O95817	Human	PMID:23434281
Molecular Function	GO:0005515	protein binding	RAPGEF6	IPI	UniProtKB:P46937	Human	PMID:24366813
Molecular Function	GO:0005515	protein binding	RAPGEF6	IPI	UniProtKB:P46937	Human	PMID:35044719
Molecular Function	GO:0031267	small GTPase binding	RAPGEF6	IDA		Human	PMID:11524421
Cellular Component	GO:0016324	apical plasma membrane	RAPGEF6	IDA		Human	PMID:22797597
Cellular Component	GO:0005813	centrosome	RAPGEF6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	RAPGEF6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	RAPGEF6	IDA		Human	PMID:22797597
Cellular Component	GO:0030139	endocytic vesicle	RAPGEF6	IDA		Human	PMID:22797597
Cellular Component	GO:0005886	plasma membrane	RAPGEF6	IDA		Human	PMID:11524421
Biological Process	GO:0030033	microvillus assembly	RAPGEF6	IGI	UniProtKB:Q9Y4G8	Human	PMID:22797597
Biological Process	GO:0043547	positive regulation of GTPase activity	RAPGEF6	IMP		Human	PMID:22797597
Biological Process	GO:0072659	protein localization to plasma membrane	RAPGEF6	IMP		Human	PMID:22797597

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern