Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRKCH
  • Mouse genes Prkch
  • Rat genes Prkch
  • Zfish genes prkcha,prkchb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prkch

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004699	calcium-independent protein kinase C activity	Prkch	IDA		Rat	PMID:1426252|RGD:729427
Molecular Function	GO:0019899	enzyme binding	PRKCH	IPI	UniProtKB:P52824	Human	PMID:15632189
Molecular Function	GO:0005515	protein binding	PRKCH	IPI	UniProtKB:Q16625-1	Human	PMID:19114660
Molecular Function	GO:0005515	protein binding	PRKCH	IPI	UniProtKB:Q28269	Human	PMID:19114660
Molecular Function	GO:0005515	protein binding	PRKCH	IPI	UniProtKB:C0HM02	Human	PMID:34593629
Molecular Function	GO:0005515	protein binding	Prkch	IPI	UniProtKB:P63321	Mouse	MGI:MGI:5306545|PMID:21346190
Molecular Function	GO:0004672	protein kinase activity	PRKCH	IDA		Human	PMID:34593629
Molecular Function	GO:0031267	small GTPase binding	Prkch	IPI	UniProtKB:P63321	Mouse	MGI:MGI:5306545|PMID:21346190
Cellular Component	GO:0005911	cell-cell junction	Prkch	IDA		Mouse	PMID:23793062
Cellular Component	GO:0005737	cytoplasm	PRKCH	IDA		Human	PMID:15632189
Cellular Component	GO:0005829	cytosol	Prkch	IDA		Mouse	MGI:MGI:5306545|PMID:21346190
Cellular Component	GO:0005829	cytosol	Prkch	IDA		Rat	PMID:9705215|RGD:5131655
Cellular Component	GO:0005829	cytosol	Prkch	IDA		Rat	PMID:9950866|RGD:5131658
Cellular Component	GO:0070062	extracellular exosome	PRKCH	HDA		Human	PMID:19056867
Cellular Component	GO:0016020	membrane	Prkch	IDA		Rat	PMID:9705215|RGD:5131655
Cellular Component	GO:0005886	plasma membrane	PRKCH	IDA		Human	PMID:15632189
Cellular Component	GO:0005886	plasma membrane	Prkch	IDA		Mouse	MGI:MGI:5306545|PMID:21346190
Biological Process	GO:0034351	negative regulation of glial cell apoptotic process	PRKCH	IMP		Human	PMID:11772428
Biological Process	GO:0050861	positive regulation of B cell receptor signaling pathway	PRKCH	IMP		Human	PMID:18780722
Biological Process	GO:0060252	positive regulation of glial cell proliferation	PRKCH	IMP		Human	PMID:10806212
Biological Process	GO:0045618	positive regulation of keratinocyte differentiation	Prkch	IMP		Mouse	MGI:MGI:5306545|PMID:21346190
Biological Process	GO:0010744	positive regulation of macrophage derived foam cell differentiation	Prkch	IMP		Mouse	MGI:MGI:5306557|PMID:20558593
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PRKCH	IMP		Human	PMID:21820409
Biological Process	GO:0070528	protein kinase C signaling	Prkch	IMP		Rat	PMID:9677361|RGD:5131657
Biological Process	GO:0006468	protein phosphorylation	PRKCH	IMP		Human	PMID:22304920
Biological Process	GO:0006468	protein phosphorylation	PRKCH	IDA		Human	PMID:34593629
Biological Process	GO:0006468	protein phosphorylation	Prkch	IDA		Rat	PMID:1426252|RGD:729427
Biological Process	GO:2000810	regulation of bicellular tight junction assembly	PRKCH	IMP		Human	PMID:19114660

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern