Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PRG2
  • Mouse genes Prg2
  • Rat genes Prg2
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Prg2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030021	extracellular matrix structural constituent conferring compression resistance	PRG2	HDA		Human	PMID:28344315
Molecular Function	GO:0005515	protein binding	PRG2	IPI	UniProtKB:Q13219	Human	PMID:12421832
Molecular Function	GO:0005515	protein binding	PRG2	IPI	UniProtKB:Q13219	Human	PMID:7685339
Cellular Component	GO:0062023	collagen-containing extracellular matrix	PRG2	HDA		Human	PMID:28344315
Cellular Component	GO:0062023	collagen-containing extracellular matrix	PRG2	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Prg2	HDA		Mouse	MGI:MGI:6201853|PMID:28071719
Cellular Component	GO:0070062	extracellular exosome	PRG2	HDA		Human	PMID:23533145
Biological Process	GO:0002215	defense response to nematode	Prg2	IMP	MGI:MGI:3027719	Mouse	PMID:16926417
Biological Process	GO:0032613	interleukin-10 production	Prg2	IMP	MGI:MGI:3027719	Mouse	PMID:16926417
Biological Process	GO:0032633	interleukin-4 production	Prg2	IMP	MGI:MGI:3027719	Mouse	PMID:16926417
Biological Process	GO:0010934	macrophage cytokine production	Prg2	IMP	MGI:MGI:3027719	Mouse	PMID:16926417
Biological Process	GO:0032693	negative regulation of interleukin-10 production	Prg2	IMP	MGI:MGI:3027719	Mouse	PMID:16926417
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	Prg2	IMP	MGI:MGI:3027719	Mouse	PMID:16926417
Biological Process	GO:0032753	positive regulation of interleukin-4 production	Prg2	IMP	MGI:MGI:3027719	Mouse	PMID:16926417

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern