Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes POLE
  • Mouse genes Pole
  • Rat genes Pole
  • Zfish genes pole
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pole

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	POLE	IDA		Human	PMID:16762037
Molecular Function	GO:0003677	DNA binding	POLE	IDA		Human	PMID:16762037
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLE	IMP		Human	PMID:16762037
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Pole	IMP		Rat	PMID:11959615|RGD:7247274
Molecular Function	GO:0005515	protein binding	POLE	IPI	UniProtKB:P56282	Human	PMID:10801849
Molecular Function	GO:0005515	protein binding	POLE	IPI	UniProtKB:P56282	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	POLE	IPI	UniProtKB:O95870	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POLE	IPI	UniProtKB:P56282	Human	PMID:32296183
Cellular Component	GO:0008622	epsilon DNA polymerase complex	POLE	IPI		Human	PMID:10801849
Cellular Component	GO:0008622	epsilon DNA polymerase complex	POLE	IDA		Human	PMID:10801849
Cellular Component	GO:0008622	epsilon DNA polymerase complex	POLE	IDA		Human	PMID:22465957
Cellular Component	GO:0005654	nucleoplasm	POLE	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	POLE	IDA		Human	PMID:16762037
Cellular Component	GO:0005886	plasma membrane	POLE	IDA		Human	GO_REF:0000052
Biological Process	GO:0006287	base-excision repair, gap-filling	POLE	IDA		Human	PMID:10559260
Biological Process	GO:0071897	DNA biosynthetic process	Pole	IMP		Rat	PMID:11959615|RGD:7247274
Biological Process	GO:0006260	DNA replication	POLE	IMP		Human	PMID:16762037
Biological Process	GO:0000731	DNA synthesis involved in DNA repair	POLE	IMP		Human	PMID:1730053
Biological Process	GO:0006261	DNA-templated DNA replication	POLE	IDA		Human	PMID:33051204
Biological Process	GO:0048568	embryonic organ development	Pole	IEP		Rat	PMID:11425516|RGD:2313673
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	POLE	IMP		Human	PMID:16762037
Biological Process	GO:0006297	nucleotide-excision repair, DNA gap filling	POLE	IMP		Human	PMID:20227374

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern