Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes POLD1
  • Mouse genes Pold1
  • Rat genes Pold1
  • Zfish genes pold1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pold1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008408	3'-5' exonuclease activity	Pold1	IMP	MGI:MGI:2447628	Mouse	PMID:12429860
Molecular Function	GO:0003682	chromatin binding	POLD1	IDA		Human	PMID:16762037
Molecular Function	GO:0003682	chromatin binding	POLD1	IDA		Human	PMID:24939902
Molecular Function	GO:0003684	damaged DNA binding	POLD1	IDA		Human	PMID:24939902
Molecular Function	GO:0003677	DNA binding	POLD1	IDA		Human	PMID:16762037
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	POLD1	IMP		Human	PMID:16762037
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Pold1	IDA		Rat	PMID:10541966|RGD:729526
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Pold1	IMP		Rat	PMID:11959615|RGD:7247274
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Pold1	IMP		Rat	PMID:7503737|RGD:2307013
Molecular Function	GO:0003887	DNA-directed DNA polymerase activity	Pold1	IDA		Rat	PMID:9620226|RGD:2299945
Molecular Function	GO:0019899	enzyme binding	Pold1	IPI	UniProtKB:Q0VGM9	Mouse	MGI:MGI:5522574|PMID:24115439
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:P49005	Human	PMID:12403614
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:Q9HCU8	Human	PMID:12403614
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:Q96S55	Human	PMID:15670210
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:P12004	Human	PMID:15805117
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:P12004	Human	PMID:16510448
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:P49005	Human	PMID:16510448
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:Q9HCU8	Human	PMID:16510448
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:Q9NYB0	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:O76071	Human	PMID:23891004
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:Q9Y3D0	Human	PMID:23891004
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:Q9Y2S7	Human	PMID:24191025
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:P12004	Human	PMID:24939902
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:P12004	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:P49005	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:Q9HCU8	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:P49005	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:P49005	Human	PMID:31449058
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:Q9HCU8	Human	PMID:31449058
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:A8MQ03	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:Q14847-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:Q53G59	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	POLD1	IPI	UniProtKB:Q6UY14-3	Human	PMID:32296183
Cellular Component	GO:0016235	aggresome	POLD1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000781	chromosome, telomeric region	POLD1	IDA		Human	PMID:24270157
Cellular Component	GO:0005829	cytosol	POLD1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043625	delta DNA polymerase complex	POLD1	IPI		Human	PMID:12403614
Cellular Component	GO:0043625	delta DNA polymerase complex	POLD1	IDA		Human	PMID:11595739
Cellular Component	GO:0043625	delta DNA polymerase complex	POLD1	IDA		Human	PMID:22465957
Cellular Component	GO:0043625	delta DNA polymerase complex	Pold1	IDA		Mouse	MGI:MGI:6383350|PMID:11595739
Cellular Component	GO:0043625	delta DNA polymerase complex	Pold1	IDA		Rat	PMID:10541966|RGD:729526
Cellular Component	GO:0016020	membrane	POLD1	HDA		Human	PMID:19946888
Cellular Component	GO:0005654	nucleoplasm	POLD1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000109	nucleotide-excision repair complex	POLD1	IDA		Human	PMID:20713449
Cellular Component	GO:0005634	nucleus	POLD1	IDA		Human	PMID:16762037
Biological Process	GO:0006287	base-excision repair, gap-filling	POLD1	IDA		Human	PMID:10559260
Biological Process	GO:0006287	base-excision repair, gap-filling	POLD1	IDA		Human	PMID:10559261
Biological Process	GO:0006287	base-excision repair, gap-filling	Pold1	IMP		Mouse	PMID:15177179
Biological Process	GO:0034644	cellular response to UV	POLD1	IDA		Human	PMID:24939902
Biological Process	GO:0071897	DNA biosynthetic process	POLD1	IDA		Human	PMID:11595739
Biological Process	GO:0071897	DNA biosynthetic process	Pold1	IDA		Mouse	MGI:MGI:6383350|PMID:11595739
Biological Process	GO:0071897	DNA biosynthetic process	Pold1	IMP		Rat	PMID:11959615|RGD:7247274
Biological Process	GO:0006260	DNA replication	POLD1	IMP		Human	PMID:16762037
Biological Process	GO:0006260	DNA replication	Pold1	IDA		Rat	PMID:10541966|RGD:729526
Biological Process	GO:0006260	DNA replication	pold1	IMP	ZFIN:ZDB-GENO-980202-1249	Zfish	PMID:16096653
Biological Process	GO:0045004	DNA replication proofreading	Pold1	IMP	MGI:MGI:2447628	Mouse	PMID:12429860
Biological Process	GO:0000731	DNA synthesis involved in DNA repair	POLD1	IMP		Human	PMID:1730053
Biological Process	GO:0000731	DNA synthesis involved in DNA repair	POLD1	IDA		Human	PMID:24191025
Biological Process	GO:0000731	DNA synthesis involved in DNA repair	POLD1	IDA		Human	PMID:3335506
Biological Process	GO:0006261	DNA-templated DNA replication	POLD1	IDA		Human	PMID:20334433
Biological Process	GO:0006261	DNA-templated DNA replication	Pold1	IMP		Rat	PMID:7503737|RGD:2307013
Biological Process	GO:0006261	DNA-templated DNA replication	Pold1	IDA		Rat	PMID:9620226|RGD:2299945
Biological Process	GO:0070987	error-free translesion synthesis	POLD1	IDA		Human	PMID:24191025
Biological Process	GO:0055089	fatty acid homeostasis	POLD1	IMP		Human	PMID:23770608
Biological Process	GO:0006297	nucleotide-excision repair, DNA gap filling	POLD1	IMP		Human	PMID:20227374

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern