Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PNPLA2
  • Mouse genes Pnpla2
  • Rat genes Pnpla2
  • Zfish genes pnpla2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pnpla2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016411	acylglycerol O-acyltransferase activity	PNPLA2	IDA		Human	PMID:17603008
Molecular Function	GO:0051265	diolein transacylation activity	PNPLA2	IDA		Human	PMID:15364929
Molecular Function	GO:0051264	mono-olein transacylation activity	PNPLA2	IDA		Human	PMID:15364929
Molecular Function	GO:0004623	phospholipase A2 activity	PNPLA2	IDA		Human	PMID:15364929
Molecular Function	GO:0004623	phospholipase A2 activity	PNPLA2	IDA		Human	PMID:17032652
Molecular Function	GO:0005515	protein binding	PNPLA2	IPI	UniProtKB:P36955	Human	PMID:17032652
Molecular Function	GO:0005515	protein binding	Pnpla2	IPI	UniProtKB:Q8BVZ1	Mouse	MGI:MGI:5559668|PMID:21148142
Molecular Function	GO:0005515	protein binding	Pnpla2	IPI	UniProtKB:Q9DBL9	Mouse	MGI:MGI:3769941|PMID:16679289
Molecular Function	GO:0005515	protein binding	Pnpla2	IPI	UniProtKB:M0R7Z9	Rat	PMID:23408028|RGD:8553342
Molecular Function	GO:0005515	protein binding	Pnpla2	IPI	UniProtKB:M0R7Z9	Rat	PMID:24303154|RGD:8553664
Molecular Function	GO:0050253	retinyl-palmitate esterase activity	PNPLA2	EXP		Human	PMID:17603008
Molecular Function	GO:0004806	triglyceride lipase activity	PNPLA2	IDA		Human	PMID:15364929
Molecular Function	GO:0004806	triglyceride lipase activity	PNPLA2	IDA		Human	PMID:15550674
Molecular Function	GO:0004806	triglyceride lipase activity	PNPLA2	IDA		Human	PMID:16150821
Molecular Function	GO:0004806	triglyceride lipase activity	PNPLA2	IMP		Human	PMID:16239926
Molecular Function	GO:0004806	triglyceride lipase activity	PNPLA2	EXP		Human	PMID:17603008
Molecular Function	GO:0004806	triglyceride lipase activity	PNPLA2	IDA		Human	PMID:17603008
Molecular Function	GO:0004806	triglyceride lipase activity	PNPLA2	IDA		Human	PMID:34903883
Molecular Function	GO:0004806	triglyceride lipase activity	Pnpla2	IDA		Mouse	MGI:MGI:6437029|PMID:15550674
Molecular Function	GO:0004806	triglyceride lipase activity	Pnpla2	IDA		Mouse	MGI:MGI:5465510|PMID:23066022
Molecular Function	GO:0004806	triglyceride lipase activity	Pnpla2	IDA		Mouse	MGI:MGI:7260096|PMID:15337759
Molecular Function	GO:0004806	triglyceride lipase activity	Pnpla2	IMP		Mouse	MGI:MGI:3624224|PMID:16675698
Molecular Function	GO:0004806	triglyceride lipase activity	Pnpla2	IDA		Mouse	MGI:MGI:3769941|PMID:16679289
Molecular Function	GO:0004806	triglyceride lipase activity	Pnpla2	IDA		Mouse	MGI:MGI:3697284|PMID:17074755
Molecular Function	GO:0004806	triglyceride lipase activity	Pnpla2	IMP		Mouse	MGI:MGI:3698700|PMID:17114792
Cellular Component	GO:0005737	cytoplasm	Pnpla2	IDA		Mouse	MGI:MGI:7260096|PMID:15337759
Cellular Component	GO:0005829	cytosol	Pnpla2	IDA		Mouse	PMID:17074755
Cellular Component	GO:0005811	lipid droplet	PNPLA2	IDA		Human	PMID:34903883
Cellular Component	GO:0005811	lipid droplet	PNPLA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005811	lipid droplet	PNPLA2	IDA		Human	PMID:16239926
Cellular Component	GO:0005811	lipid droplet	PNPLA2	IDA		Human	PMID:21498505
Cellular Component	GO:0005811	lipid droplet	Pnpla2	IDA		Mouse	MGI:MGI:6437029|PMID:15550674
Cellular Component	GO:0005811	lipid droplet	Pnpla2	IDA		Mouse	MGI:MGI:5559668|PMID:21148142
Cellular Component	GO:0005654	nucleoplasm	PNPLA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	PNPLA2	IDA		Human	PMID:17032652
Biological Process	GO:0044242	cellular lipid catabolic process	Pnpla2	IMP		Mouse	PMID:26427354
Biological Process	GO:0006651	diacylglycerol biosynthetic process	Pnpla2	IDA		Mouse	MGI:MGI:5465510|PMID:23066022
Biological Process	GO:1905691	lipid droplet disassembly	PNPLA2	IMP		Human	PMID:16239926
Biological Process	GO:0034389	lipid droplet organization	Pnpla2	IMP		Mouse	PMID:23297223
Biological Process	GO:0019915	lipid storage	Pnpla2	IMP		Mouse	MGI:MGI:5559668|PMID:21148142
Biological Process	GO:0010891	negative regulation of sequestering of triglyceride	PNPLA2	IDA		Human	PMID:16679289
Biological Process	GO:0010891	negative regulation of sequestering of triglyceride	Pnpla2	IDA		Mouse	MGI:MGI:3769941|PMID:16679289
Biological Process	GO:0010898	positive regulation of triglyceride catabolic process	PNPLA2	IDA		Human	PMID:16679289
Biological Process	GO:0010898	positive regulation of triglyceride catabolic process	Pnpla2	IDA		Mouse	MGI:MGI:3769941|PMID:16679289
Biological Process	GO:0019433	triglyceride catabolic process	Pnpla2	IDA		Mouse	MGI:MGI:5465510|PMID:23066022
Biological Process	GO:0019433	triglyceride catabolic process	Pnpla2	IMP		Mouse	MGI:MGI:3624224|PMID:16675698
Biological Process	GO:0019433	triglyceride catabolic process	Pnpla2	IMP	MGI:MGI:3629035	Mouse	PMID:17074755

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern