Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PMEPA1
  • Mouse genes Pmepa1
  • Rat genes Pmepa1
  • Zfish genes ldlrad4a,pmepa1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pmepa1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	PMEPA1	IPI	UniProtKB:O15165-1	Human	PMID:24627487
Molecular Function	GO:0005515	protein binding	Pmepa1	IPI	UniProtKB:O08758	Mouse	PMID:11042109
Molecular Function	GO:0070412	R-SMAD binding	PMEPA1	IPI	UniProtKB:Q15796	Human	PMID:20129061
Molecular Function	GO:0050699	WW domain binding	PMEPA1	IPI	UniProtKB:P46934	Human	PMID:12907594
Cellular Component	GO:0031901	early endosome membrane	PMEPA1	IDA		Human	PMID:24627487
Cellular Component	GO:0010008	endosome membrane	PMEPA1	IDA		Human	PMID:20129061
Cellular Component	GO:0000139	Golgi membrane	PMEPA1	IDA		Human	PMID:20129061
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	PMEPA1	IDA		Human	GO_REF:0000052
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	PMEPA1	IMP		Human	PMID:20129061
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	PMEPA1	IDA		Human	PMID:24627487
Biological Process	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	Pmepa1	IDA		Mouse	MGI:MGI:5582164|PMID:20129061
Biological Process	GO:0010991	negative regulation of SMAD protein complex assembly	PMEPA1	IDA		Human	PMID:20129061
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	PMEPA1	IMP		Human	PMID:20129061
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	PMEPA1	IDA		Human	PMID:24627487
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Pmepa1	IDA		Mouse	MGI:MGI:5582164|PMID:20129061

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern