Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PLEKHF1
  • Mouse genes Plekhf1
  • Rat genes Plekhf1
  • Zfish genes plekhf1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Plekhf1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0032266	phosphatidylinositol-3-phosphate binding	PLEKHF1	IDA		Human	PMID:22115783
Molecular Function	GO:0070273	phosphatidylinositol-4-phosphate binding	PLEKHF1	IDA		Human	PMID:22115783
Molecular Function	GO:0010314	phosphatidylinositol-5-phosphate binding	PLEKHF1	IDA		Human	PMID:22115783
Molecular Function	GO:0005515	protein binding	PLEKHF1	IPI	UniProtKB:Q96JM7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PLEKHF1	IPI	UniProtKB:O95379	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLEKHF1	IPI	UniProtKB:O95810	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLEKHF1	IPI	UniProtKB:Q86SE8-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLEKHF1	IPI	UniProtKB:Q96JM7-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PLEKHF1	IPI	UniProtKB:Q9UKJ5	Human	PMID:32296183
Cellular Component	GO:0005768	endosome	PLEKHF1	IDA		Human	PMID:22115783
Cellular Component	GO:0005764	lysosome	PLEKHF1	IDA		Human	PMID:22115783
Cellular Component	GO:0005764	lysosome	Plekhf1	IDA		Mouse	PMID:16188880
Biological Process	GO:0007032	endosome organization	PLEKHF1	IMP		Human	PMID:22115783
Biological Process	GO:0010508	positive regulation of autophagy	PLEKHF1	IDA		Human	PMID:22115783
Biological Process	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	Plekhf1	IDA		Mouse	PMID:16188880
Biological Process	GO:0072659	protein localization to plasma membrane	PLEKHF1	IMP		Human	PMID:22115783
Biological Process	GO:0016050	vesicle organization	PLEKHF1	IMP		Human	PMID:22115783

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern