Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Pfkm

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PFKM
- Mouse genes Pfkm
- Rat genes Pfkm
- Zfish genes pfkma,pfkmb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pfkm

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003872	6-phosphofructokinase activity	PFKM	IMP		Human	PMID:25796446
Molecular Function	GO:0003872	6-phosphofructokinase activity	PFKM	IMP		Human	PMID:6444532
Molecular Function	GO:0003872	6-phosphofructokinase activity	PFKM	IDA		Human	PMID:6444721
Molecular Function	GO:0003872	6-phosphofructokinase activity	PFKM	IDA		Human	PMID:8780720
Molecular Function	GO:0003872	6-phosphofructokinase activity	Pfkm	IMP	MGI:MGI:4356541	Mouse	PMID:19696889
Molecular Function	GO:0003872	6-phosphofructokinase activity	Pfkm	IDA		Mouse	PMID:19889946
Molecular Function	GO:0003872	6-phosphofructokinase activity	Pfkm	IDA		Mouse	PMID:17720578
Molecular Function	GO:0003872	6-phosphofructokinase activity	Pfkm	IMP	MGI:MGI:3759504	Mouse	PMID:17595219
Molecular Function	GO:0003872	6-phosphofructokinase activity	Pfkm	IDA		Mouse	PMID:2521854
Molecular Function	GO:0003872	6-phosphofructokinase activity	Pfkm	IDA		Rat	PMID:12161\|RGD:2302675
Molecular Function	GO:0003872	6-phosphofructokinase activity	Pfkm	IDA		Rat	PMID:2931076\|RGD:2302736
Molecular Function	GO:0003872	6-phosphofructokinase activity	Pfkm	IDA		Rat	PMID:3159721\|RGD:2302676
Molecular Function	GO:0003872	6-phosphofructokinase activity	Pfkm	IDA		Rat	PMID:8593533\|RGD:1599363
Molecular Function	GO:0016208	AMP binding	Pfkm	IDA		Rat	PMID:12161\|RGD:2302675
Molecular Function	GO:0016208	AMP binding	Pfkm	IDA		Rat	PMID:3159721\|RGD:2302676
Molecular Function	GO:0005524	ATP binding	PFKM	IDA		Human	PMID:8780720
Molecular Function	GO:0005524	ATP binding	Pfkm	IDA		Rat	PMID:12161\|RGD:2302675
Molecular Function	GO:0005524	ATP binding	Pfkm	IDA		Rat	PMID:2931076\|RGD:2302736
Molecular Function	GO:0005524	ATP binding	Pfkm	IDA		Rat	PMID:3159721\|RGD:2302676
Molecular Function	GO:0030246	carbohydrate binding	Pfkm	IDA		Rat	PMID:8593533\|RGD:1599363
Molecular Function	GO:0070061	fructose binding	PFKM	IDA		Human	PMID:8780720
Molecular Function	GO:0070095	fructose-6-phosphate binding	Pfkm	IDA		Rat	PMID:12161\|RGD:2302675
Molecular Function	GO:0070095	fructose-6-phosphate binding	Pfkm	IDA		Rat	PMID:2931076\|RGD:2302736
Molecular Function	GO:0070095	fructose-6-phosphate binding	Pfkm	IDA		Rat	PMID:3159721\|RGD:2302676
Molecular Function	GO:0042802	identical protein binding	PFKM	IPI	UniProtKB:P08237	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	PFKM	IPI	UniProtKB:P08237	Human	PMID:6444721
Molecular Function	GO:0042802	identical protein binding	Pfkm	IPI	PR:P47857	Mouse	PMID:19889946
Molecular Function	GO:0042802	identical protein binding	Pfkm	IPI	RGD:68419	Rat	PMID:2931076\|RGD:2302736
Molecular Function	GO:0019900	kinase binding	PFKM	IPI	UniProtKB:P17858	Human	PMID:6444721
Molecular Function	GO:0008443	phosphofructokinase activity	Pfkm	IDA		Mouse	PMID:11785984
Molecular Function	GO:0008443	phosphofructokinase activity	Pfkm	IMP		Rat	PMID:14522413\|RGD:1599124
Molecular Function	GO:0005515	protein binding	PFKM	IPI	UniProtKB:Q9HBG4	Human	PMID:12649290
Molecular Function	GO:0005515	protein binding	PFKM	IPI	UniProtKB:P17858	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	PFKM	IPI	UniProtKB:Q8IUQ4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PFKM	IPI	UniProtKB:P28347	Human	PMID:25796446
Molecular Function	GO:0005515	protein binding	PFKM	IPI	UniProtKB:P28347,UniProtKB:P46937	Human	PMID:25796446
Molecular Function	GO:0005515	protein binding	PFKM	IPI	UniProtKB:Q15561	Human	PMID:25796446
Molecular Function	GO:0005515	protein binding	PFKM	IPI	UniProtKB:P17858	Human	PMID:6444721
Cellular Component	GO:0005945	6-phosphofructokinase complex	PFKM	IDA		Human	PMID:6444532
Cellular Component	GO:0005945	6-phosphofructokinase complex	PFKM	IDA		Human	PMID:6444721
Cellular Component	GO:0016324	apical plasma membrane	PFKM	IDA		Human	PMID:12649290
Cellular Component	GO:0005829	cytosol	Pfkm	IDA		Mouse	PMID:21347706
Cellular Component	GO:0005829	cytosol	Pfkm	IDA		Mouse	PMID:2521854
Cellular Component	GO:0005634	nucleus	PFKM	IDA		Human	PMID:25796446
Cellular Component	GO:0097228	sperm principal piece	Pfkm	IDA		Mouse	PMID:19889946
Biological Process	GO:0061621	canonical glycolysis	Pfkm	IDA		Mouse	PMID:28049690
Biological Process	GO:0061621	canonical glycolysis	Pfkm	IDA		Mouse	PMID:4275392
Biological Process	GO:0061621	canonical glycolysis	Pfkm	IGI	MGI:MGI:1196256	Mouse	PMID:27760309
Biological Process	GO:0061621	canonical glycolysis	Pfkm	IMP	MGI:MGI:4356541	Mouse	PMID:19696889
Biological Process	GO:0030388	fructose 1,6-bisphosphate metabolic process	Pfkm	IDA		Rat	PMID:12161\|RGD:2302675
Biological Process	GO:0030388	fructose 1,6-bisphosphate metabolic process	Pfkm	IDA		Rat	PMID:2931076\|RGD:2302736
Biological Process	GO:0030388	fructose 1,6-bisphosphate metabolic process	Pfkm	IDA		Rat	PMID:3159721\|RGD:2302676
Biological Process	GO:0030388	fructose 1,6-bisphosphate metabolic process	Pfkm	IDA		Rat	PMID:8593533\|RGD:1599363
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	PFKM	IMP		Human	PMID:6444532
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	PFKM	IDA		Human	PMID:6444721
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	Pfkm	IDA		Rat	PMID:12161\|RGD:2302675
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	Pfkm	IDA		Rat	PMID:2931076\|RGD:2302736
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	Pfkm	IDA		Rat	PMID:3159721\|RGD:2302676
Biological Process	GO:0006002	fructose 6-phosphate metabolic process	Pfkm	IDA		Rat	PMID:8593533\|RGD:1599363
Biological Process	GO:0042593	glucose homeostasis	Pfkm	IMP	MGI:MGI:3759504	Mouse	PMID:17595219
Biological Process	GO:0005980	glycogen catabolic process	Pfkm	IMP	MGI:MGI:4356541	Mouse	PMID:19696889
Biological Process	GO:0093001	glycolysis from storage polysaccharide through glucose-1-phosphate	Pfkm	IMP	MGI:MGI:4356541	Mouse	PMID:19696889
Biological Process	GO:0006096	glycolytic process	PFKM	IMP		Human	PMID:6444532
Biological Process	GO:0006096	glycolytic process	Pfkm	IDA		Rat	PMID:2931076\|RGD:2302736
Biological Process	GO:0006096	glycolytic process	Pfkm	IDA		Rat	PMID:8593533\|RGD:1599363
Biological Process	GO:0061615	glycolytic process through fructose-6-phosphate	PFKM	IMP		Human	PMID:25796446
Biological Process	GO:0061615	glycolytic process through fructose-6-phosphate	Pfkm	IDA		Mouse	PMID:19889946
Biological Process	GO:0061615	glycolytic process through fructose-6-phosphate	Pfkm	IDA		Mouse	PMID:2521854
Biological Process	GO:0061615	glycolytic process through fructose-6-phosphate	Pfkm	IMP	MGI:MGI:3759504	Mouse	PMID:17595219
Biological Process	GO:0046716	muscle cell cellular homeostasis	PFKM	IMP		Human	PMID:6444532
Biological Process	GO:0032024	positive regulation of insulin secretion	Pfkm	IMP	MGI:MGI:3759504	Mouse	PMID:17595219
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	PFKM	IMP		Human	PMID:25796446

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.