Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PFKFB2
  • Mouse genes Pfkfb2
  • Rat genes Pfkfb2
  • Zfish genes pfkfb2a,pfkfb2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pfkfb2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003873	6-phosphofructo-2-kinase activity	PFKFB2	IDA		Human	PMID:11069105
Molecular Function	GO:0003873	6-phosphofructo-2-kinase activity	Pfkfb2	IMP	MGI:MGI:3640602	Mouse	PMID:15331593
Molecular Function	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	Pfkfb2	IDA		Mouse	MGI:MGI:3796388|PMID:18039179
Molecular Function	GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	Pfkfb2	IDA		Rat	PMID:18039179|RGD:10047326
Molecular Function	GO:0019209	kinase activator activity	Pfkfb2	IMP	MGI:MGI:3640602	Mouse	PMID:15331593
Molecular Function	GO:0019900	kinase binding	Pfkfb2	IPI	RGD:69130	Rat	PMID:11522786|RGD:2302683
Molecular Function	GO:0005515	protein binding	PFKFB2	IPI	UniProtKB:P63104	Human	PMID:15161933
Molecular Function	GO:0005515	protein binding	PFKFB2	IPI	UniProtKB:P63104	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PFKFB2	IPI	UniProtKB:P09467	Human	PMID:8387495
Molecular Function	GO:0019901	protein kinase binding	PFKFB2	IPI	UniProtKB:P54645	Human	PMID:11069105
Molecular Function	GO:0019901	protein kinase binding	PFKFB2	IPI	UniProtKB:Q09137	Human	PMID:11069105
Cellular Component	GO:0005737	cytoplasm	Pfkfb2	IDA		Rat	PMID:16980436|RGD:2304071
Cellular Component	GO:0005654	nucleoplasm	PFKFB2	IDA		Human	GO_REF:0000052
Biological Process	GO:0046835	carbohydrate phosphorylation	Pfkfb2	IMP	MGI:MGI:3640602	Mouse	MGI:MGI:3512852|PMID:15331593
Biological Process	GO:0006007	glucose catabolic process	Pfkfb2	IDA		Rat	PMID:16980436|RGD:2304071
Biological Process	GO:0006096	glycolytic process	PFKFB2	IDA		Human	PMID:11069105
Biological Process	GO:0006089	lactate metabolic process	Pfkfb2	IDA		Rat	PMID:16980436|RGD:2304071
Biological Process	GO:0033133	positive regulation of glucokinase activity	Pfkfb2	IDA		Rat	PMID:16980436|RGD:2304071
Biological Process	GO:0032024	positive regulation of insulin secretion	Pfkfb2	IDA		Rat	PMID:16980436|RGD:2304071
Biological Process	GO:0006090	pyruvate metabolic process	Pfkfb2	IDA		Rat	PMID:16980436|RGD:2304071
Biological Process	GO:0009749	response to glucose	Pfkfb2	IDA		Rat	PMID:16980436|RGD:2304071

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern