Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDE9A
  • Mouse genes Pde9a
  • Rat genes Pde9a
  • Zfish genes pde9aa,pde9ab,pde9ac
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pde9a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	PDE9A	IDA		Human	PMID:25799991
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	PDE9A	IDA		Human	PMID:9624146
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	Pde9a	IDA		Mouse	PMID:9624145
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	Pde9a	IDA		Rat	PMID:14501210|RGD:724613
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:Q13049	Human	PMID:16189514
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:Q13049	Human	PMID:19060904
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:O95817	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:P25791	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:P49759	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:P49888	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:P60410	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:Q13049	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:Q14657	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:Q49AN0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:Q7Z3S9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:Q8NAJ2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:Q96FC7-2	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:Q9BRA0	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:Q9BRU9	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:Q9BYQ4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:Q9BYR5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:Q9H8Y8	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:Q9Y260	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:O76083-2	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:Q13049	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:Q9H8Y8	Human	PMID:29892012
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:Q13049	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	PDE9A	IPI	UniProtKB:Q7Z3S9	Human	PMID:31515488
Cellular Component	GO:0005829	cytosol	PDE9A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	PDE9A	HDA		Human	PMID:16780588
Cellular Component	GO:0005654	nucleoplasm	PDE9A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043204	perikaryon	Pde9a	IDA		Rat	PMID:19445908|RGD:2312501
Cellular Component	GO:0005886	plasma membrane	PDE9A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0042383	sarcolemma	PDE9A	IDA		Human	PMID:25799991
Biological Process	GO:0046069	cGMP catabolic process	PDE9A	IDA		Human	PMID:25799991
Biological Process	GO:0046069	cGMP catabolic process	Pde9a	IDA		Mouse	MGI:MGI:1266874|PMID:9624145
Biological Process	GO:0046069	cGMP catabolic process	Pde9a	IMP		Mouse	MGI:MGI:5634842|PMID:25799991
Biological Process	GO:0046068	cGMP metabolic process	PDE9A	IDA		Human	PMID:9624146
Biological Process	GO:0019934	cGMP-mediated signaling	Pde9a	IEP		Rat	PMID:14501210|RGD:724613
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	Pde9a	IMP		Mouse	MGI:MGI:5634842|PMID:25799991

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern