Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDE8B
  • Mouse genes Pde8b
  • Rat genes Pde8b
  • Zfish genes pde8b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pde8b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	PDE8B	IMP		Human	PMID:9784418
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Pde8b	IDA		Mouse	PMID:21187369
Biological Process	GO:0001662	behavioral fear response	Pde8b	IMP		Mouse	PMID:22925203
Biological Process	GO:0046676	negative regulation of insulin secretion	Pde8b	IMP		Rat	PMID:17991719|RGD:2312519
Biological Process	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	Pde8b	IMP		Rat	PMID:18706893|RGD:2302857
Biological Process	GO:0090032	negative regulation of steroid hormone biosynthetic process	Pde8b	IMP	MGI:MGI:5526098	Mouse	PMID:21187369
Biological Process	GO:0050885	neuromuscular process controlling balance	Pde8b	IMP		Mouse	PMID:22925203
Biological Process	GO:0035106	operant conditioning	Pde8b	IMP		Mouse	PMID:22925203
Biological Process	GO:0008542	visual learning	Pde8b	IMP		Mouse	PMID:22925203

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern