Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDE8A
  • Mouse genes Pde8a
  • Rat genes Pde8a
  • Zfish genes pde8a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pde8a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	PDE8A	IMP		Human	PMID:9618252
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Pde8a	IDA		Mouse	PMID:9671792
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	PDE8A	IDA		Human	PMID:9618252
Molecular Function	GO:0019900	kinase binding	PDE8A	IPI	UniProtKB:P04049	Human	PMID:23509299
Cellular Component	GO:0070062	extracellular exosome	PDE8A	HDA		Human	PMID:19056867
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	PDE8A	IMP		Human	PMID:23509299
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	Pde8a	IMP		Mouse	MGI:MGI:5484722|PMID:23509299
Biological Process	GO:0060548	negative regulation of cell death	PDE8A	IMP		Human	PMID:23509299
Biological Process	GO:1903206	negative regulation of hydrogen peroxide-induced cell death	PDE8A	IMP		Human	PMID:23509299
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PDE8A	IMP		Human	PMID:23509299
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Pde8a	IMP		Mouse	MGI:MGI:5484722|PMID:23509299
Biological Process	GO:0001934	positive regulation of protein phosphorylation	PDE8A	IMP		Human	PMID:23509299

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern