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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Pde8a

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pde8a
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:00041153',5'-cyclic-AMP phosphodiesterase activityPDE8AIMPHumanPMID:9618252
Molecular FunctionGO:00041153',5'-cyclic-AMP phosphodiesterase activityPde8aIDAMousePMID:9671792
Molecular FunctionGO:00475553',5'-cyclic-GMP phosphodiesterase activityPDE8AIDAHumanPMID:9618252
Molecular FunctionGO:0019900kinase bindingPDE8AIPIUniProtKB:P04049HumanPMID:23509299
Cellular ComponentGO:0070062extracellular exosomePDE8AHDAHumanPMID:19056867
Biological ProcessGO:0071364cellular response to epidermal growth factor stimulusPDE8AIMPHumanPMID:23509299
Biological ProcessGO:0071364cellular response to epidermal growth factor stimulusPde8aIMPMouseMGI:MGI:5484722|PMID:23509299
Biological ProcessGO:0060548negative regulation of cell deathPDE8AIMPHumanPMID:23509299
Biological ProcessGO:1903206negative regulation of hydrogen peroxide-induced cell deathPDE8AIMPHumanPMID:23509299
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadePDE8AIMPHumanPMID:23509299
Biological ProcessGO:0070374positive regulation of ERK1 and ERK2 cascadePde8aIMPMouseMGI:MGI:5484722|PMID:23509299
Biological ProcessGO:0001934positive regulation of protein phosphorylationPDE8AIMPHumanPMID:23509299

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory