Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDE3B
  • Mouse genes Pde3b
  • Rat genes Pde3b
  • Zfish genes pde3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pde3b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	PDE3B	IDA		Human	PMID:14592490
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Pde3b	IDA		Mouse	MGI:MGI:3793904|PMID:10454575
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Pde3b	IDA		Rat	PMID:12169692|RGD:729537
Molecular Function	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Pde3b	IDA		Rat	PMID:9631240|RGD:152995557
Molecular Function	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	Pde3b	IDA		Rat	PMID:9631240|RGD:152995557
Molecular Function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE3B	EXP		Human	PMID:8562305
Molecular Function	GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE3B	EXP		Human	PMID:9102399
Molecular Function	GO:0051219	phosphoprotein binding	Pde3b	IDA		Rat	PMID:16225849|RGD:2312535
Molecular Function	GO:0005515	protein binding	PDE3B	IPI	UniProtKB:P31946	Human	PMID:17255105
Molecular Function	GO:0005515	protein binding	PDE3B	IPI	UniProtKB:Q04917	Human	PMID:17255105
Molecular Function	GO:0005515	protein binding	PDE3B	IPI	UniProtKB:O95398	Human	PMID:21393242
Molecular Function	GO:0005515	protein binding	PDE3B	IPI	UniProtKB:P48736	Human	PMID:21393242
Molecular Function	GO:0005515	protein binding	PDE3B	IPI	UniProtKB:Q5UE93	Human	PMID:21393242
Molecular Function	GO:0005515	protein binding	PDE3B	IPI	UniProtKB:O60760	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PDE3B	IPI	UniProtKB:Q8TBB1	Human	PMID:32296183
Molecular Function	GO:0043422	protein kinase B binding	Pde3b	IPI	UniProtKB:P47196	Mouse	MGI:MGI:3793904|PMID:10454575
Cellular Component	GO:0005783	endoplasmic reticulum	Pde3b	IDA		Mouse	MGI:MGI:3843445|PMID:10952971
Cellular Component	GO:0005794	Golgi apparatus	Pde3b	IDA		Mouse	MGI:MGI:3843445|PMID:10952971
Cellular Component	GO:0032045	guanyl-nucleotide exchange factor complex	PDE3B	IDA		Human	PMID:17884339
Cellular Component	GO:0016020	membrane	PDE3B	IDA		Human	PMID:18586889
Cellular Component	GO:0016020	membrane	PDE3B	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	Pde3b	IDA		Mouse	MGI:MGI:3793904|PMID:10454575
Cellular Component	GO:0016020	membrane	Pde3b	IDA		Mouse	MGI:MGI:3843445|PMID:10952971
Biological Process	GO:0032869	cellular response to insulin stimulus	Pde3b	IEP		Mouse	MGI:MGI:3793904|PMID:10454575
Biological Process	GO:0031018	endocrine pancreas development	Pde3b	IDA		Mouse	PMID:14736883
Biological Process	GO:0042593	glucose homeostasis	Pde3b	IDA		Mouse	PMID:14736883
Biological Process	GO:0016525	negative regulation of angiogenesis	PDE3B	IMP		Human	PMID:21393242
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	Pde3b	IMP		Rat	PMID:9884079|RGD:2312525
Biological Process	GO:0007162	negative regulation of cell adhesion	PDE3B	IMP		Human	PMID:17884339
Biological Process	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	Pde3b	IMP		Rat	PMID:18706893|RGD:2302857
Biological Process	GO:0050995	negative regulation of lipid catabolic process	PDE3B	IMP		Human	PMID:11641262
Biological Process	GO:0050796	regulation of insulin secretion	Pde3b	IDA		Mouse	PMID:14736883

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern