Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PCK2
  • Mouse genes Pck2
  • Rat genes Pck2
  • Zfish genes pck2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pck2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	PCK2	EXP		Human	PMID:9657976
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	Pck2	IDA		Mouse	PMID:23466304
Molecular Function	GO:0004613	phosphoenolpyruvate carboxykinase (GTP) activity	Pck2	IDA		Rat	PMID:6049928|RGD:2302971
Molecular Function	GO:0004611	phosphoenolpyruvate carboxykinase activity	Pck2	IDA		Rat	PMID:11440903|RGD:2302970
Molecular Function	GO:0004611	phosphoenolpyruvate carboxykinase activity	Pck2	IDA		Rat	PMID:4353083|RGD:2302851
Molecular Function	GO:0005515	protein binding	PCK2	IPI	UniProtKB:P84022	Human	PMID:21988832
Cellular Component	GO:0005759	mitochondrial matrix	Pck2	IDA		Mouse	PMID:23466304
Cellular Component	GO:0005739	mitochondrion	PCK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Pck2	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Pck2	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Pck2	IDA		Rat	PMID:6049928|RGD:2302971
Biological Process	GO:0071333	cellular response to glucose stimulus	Pck2	IEP		Rat	PMID:19635791|RGD:7242950
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Pck2	IEP		Rat	PMID:19268478|RGD:10427879
Biological Process	GO:0006094	gluconeogenesis	Pck2	IGI	MGI:MGI:97501	Mouse	PMID:23466304
Biological Process	GO:0006094	gluconeogenesis	Pck2	IDA		Rat	PMID:11440903|RGD:2302970
Biological Process	GO:0006094	gluconeogenesis	Pck2	IDA		Rat	PMID:4353083|RGD:2302851
Biological Process	GO:0006094	gluconeogenesis	Pck2	IDA		Rat	PMID:6049928|RGD:2302971
Biological Process	GO:0006116	NADH oxidation	Pck2	IDA		Rat	PMID:19635791|RGD:7242950
Biological Process	GO:0006116	NADH oxidation	Pck2	IMP		Rat	PMID:19635791|RGD:7242950
Biological Process	GO:0006107	oxaloacetate metabolic process	Pck2	IDA		Rat	PMID:6049928|RGD:2302971
Biological Process	GO:0032024	positive regulation of insulin secretion	Pck2	IMP		Rat	PMID:19635791|RGD:7242950
Biological Process	GO:0006090	pyruvate metabolic process	Pck2	IMP		Rat	PMID:19635791|RGD:7242950
Biological Process	GO:0071548	response to dexamethasone	Pck2	IEP		Rat	PMID:16570165|RGD:1625508
Biological Process	GO:0032496	response to lipopolysaccharide	Pck2	IEP		Rat	PMID:19268478|RGD:10427879

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern