Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PAK4
  • Mouse genes Pak4
  • Rat genes Pak4
  • Zfish genes pak4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pak4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0098641	cadherin binding involved in cell-cell adhesion	PAK4	HDA		Human	PMID:25468996
Molecular Function	GO:0005515	protein binding	PAK4	IPI	UniProtKB:P63104	Human	PMID:15161933
Molecular Function	GO:0005515	protein binding	PAK4	IPI	UniProtKB:P60953	Human	PMID:20936779
Molecular Function	GO:0005515	protein binding	PAK4	IPI	UniProtKB:P54274	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	PAK4	IPI	UniProtKB:P60953	Human	PMID:22653441
Molecular Function	GO:0005515	protein binding	PAK4	IPI	UniProtKB:Q8TEC5	Human	PMID:24130170
Molecular Function	GO:0005515	protein binding	PAK4	IPI	UniProtKB:Q9P258	Human	PMID:25074804
Molecular Function	GO:0005515	protein binding	PAK4	IPI	UniProtKB:Q96EL1	Human	PMID:26607847
Molecular Function	GO:0005515	protein binding	PAK4	IPI	UniProtKB:Q9NTI7	Human	PMID:26607847
Molecular Function	GO:0005515	protein binding	PAK4	IPI	UniProtKB:P63104	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PAK4	IPI	UniProtKB:O00401	Human	PMID:29100370
Molecular Function	GO:0005515	protein binding	PAK4	IPI	UniProtKB:P63104	Human	PMID:29100370
Molecular Function	GO:0005515	protein binding	PAK4	IPI	UniProtKB:P60953	Human	PMID:29734338
Molecular Function	GO:0005515	protein binding	PAK4	IPI	UniProtKB:Q96EL1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	PAK4	IPI	UniProtKB:P60953	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	PAK4	IPI	UniProtKB:P63104	Human	PMID:32707033
Molecular Function	GO:0004672	protein kinase activity	Pak4	IDA		Mouse	PMID:23509247
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PAK4	IMP		Human	PMID:21788589
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PAK4	IDA		Human	PMID:26607847
Cellular Component	GO:0005912	adherens junction	PAK4	HDA		Human	PMID:25468996
Cellular Component	GO:0005925	focal adhesion	PAK4	HDA		Human	PMID:21423176
Biological Process	GO:0071407	cellular response to organic cyclic compound	Pak4	IDA		Mouse	PMID:23509247
Biological Process	GO:0060996	dendritic spine development	Pak4	IGI	MGI:MGI:95564	Mouse	PMID:23509247
Biological Process	GO:0048598	embryonic morphogenesis	pak4	IMP	ZFIN:ZDB-MRPHLNO-130408-5,ZFIN:ZDB-MRPHLNO-130408-6,ZFIN:ZDB-MRPHLNO-130408-7	Zfish	PMID:23032194
Biological Process	GO:0002573	myeloid leukocyte differentiation	pak4	IMP	ZFIN:ZDB-MRPHLNO-130408-5,ZFIN:ZDB-MRPHLNO-130408-6,ZFIN:ZDB-MRPHLNO-130408-7	Zfish	PMID:23032194
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	PAK4	IMP		Human	PMID:21788589
Biological Process	GO:0045766	positive regulation of angiogenesis	PAK4	IMP		Human	PMID:21788589

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern