Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes OTOP1
  • Mouse genes Otop1
  • Rat genes Otop1
  • Zfish genes otop1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Otop1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015485	cholesterol binding	otop1	IDA		Zfish	PMID:31160780
Molecular Function	GO:0042802	identical protein binding	otop1	IPI	UniProtKB:Q7ZWK8	Zfish	PMID:31160780|ZFIN:ZDB-PUB-190605-8
Molecular Function	GO:0042802	identical protein binding	otop1	IPI	ZDB:ZDB-GENE-030131-1613	Zfish	PMID:31160780
Molecular Function	GO:0015252	proton channel activity	OTOP1	IDA		Human	PMID:29371428
Molecular Function	GO:0015252	proton channel activity	Otop1	IDA		Mouse	MGI:MGI:6148496|PMID:29371428
Molecular Function	GO:0015252	proton channel activity	otop1	IDA		Zfish	PMID:31160780
Cellular Component	GO:0016020	membrane	Otop1	IDA		Mouse	PMID:12651873
Cellular Component	GO:0016020	membrane	otop1	IDA		Zfish	PMID:31160780
Cellular Component	GO:0005886	plasma membrane	Otop1	IDA		Mouse	MGI:MGI:6148496|PMID:29371428
Biological Process	GO:0032869	cellular response to insulin stimulus	Otop1	IMP		Mouse	MGI:MGI:5750846|PMID:24379350
Biological Process	GO:0009590	detection of gravity	Otop1	IMP	MGI:MGI:2655558	Mouse	PMID:12651873
Biological Process	GO:0009590	detection of gravity	Otop1	IMP	MGI:MGI:1856638	Mouse	PMID:12651873
Biological Process	GO:0042472	inner ear morphogenesis	Otop1	IMP	MGI:MGI:2655558	Mouse	PMID:12651873
Biological Process	GO:0042472	inner ear morphogenesis	Otop1	IMP	MGI:MGI:1856638	Mouse	PMID:12651873
Biological Process	GO:0042472	inner ear morphogenesis	otop1	IMP	ZFIN:ZDB-GENO-980202-833	Zfish	PMID:15480759
Biological Process	GO:0042472	inner ear morphogenesis	otop1	IMP		Zfish	PMID:15480759
Biological Process	GO:0060336	negative regulation of type II interferon-mediated signaling pathway	Otop1	IMP		Mouse	MGI:MGI:5750846|PMID:24379350
Biological Process	GO:0032475	otolith formation	otop1	IMP	ZFIN:ZDB-GENO-980202-833	Zfish	PMID:9007244
Biological Process	GO:0045299	otolith mineralization	otop1	IMP		Zfish	PMID:15581873
Biological Process	GO:0045299	otolith mineralization	otop1	IMP		Zfish	PMID:15480759
Biological Process	GO:0045299	otolith mineralization	otop1	IMP	ZFIN:ZDB-GENO-980202-833	Zfish	PMID:15480759
Biological Process	GO:1902600	proton transmembrane transport	OTOP1	IDA		Human	PMID:29371428
Biological Process	GO:1902600	proton transmembrane transport	Otop1	IDA		Mouse	MGI:MGI:6148496|PMID:29371428
Biological Process	GO:1902600	proton transmembrane transport	otop1	IDA		Zfish	PMID:31160780

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern