Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes OTOF
  • Mouse genes Otof
  • Rat genes Otof
  • Zfish genes otofa,otofb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Otof

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0035612	AP-2 adaptor complex binding	Otof	IDA		Mouse	PMID:23719817
Molecular Function	GO:0005509	calcium ion binding	Otof	IDA		Mouse	MGI:MGI:3692845|PMID:17055430
Molecular Function	GO:0005515	protein binding	Otof	IPI	UniProtKB:O35526|UniProtKB:P60879|UniProtKB:P61028	Mouse	MGI:MGI:3692845|PMID:17055430
Molecular Function	GO:0005515	protein binding	Otof	IPI	RGD:628764	Rat	PMID:18772196|RGD:9491383
Molecular Function	GO:0044877	protein-containing complex binding	Otof	IPI	RGD:1306254	Rat	PMID:23719817|RGD:9491749
Molecular Function	GO:0044877	protein-containing complex binding	Otof	IPI	RGD:71015	Rat	PMID:23719817|RGD:9491749
Cellular Component	GO:0045177	apical part of cell	Otof	IDA		Rat	PMID:23719817|RGD:9491749
Cellular Component	GO:0045178	basal part of cell	Otof	IDA		Rat	PMID:23719817|RGD:9491749
Cellular Component	GO:0005737	cytoplasm	Otof	IDA		Rat	PMID:17229086|RGD:2316502
Cellular Component	GO:0005783	endoplasmic reticulum	Otof	IDA		Mouse	PMID:27458190
Cellular Component	GO:0005783	endoplasmic reticulum	Otof	IDA		Rat	PMID:18772196|RGD:9491383
Cellular Component	GO:0005886	plasma membrane	Otof	IDA		Rat	PMID:18772196|RGD:9491383
Cellular Component	GO:0048787	presynaptic active zone membrane	Otof	IDA		Mouse	PMID:25609709
Cellular Component	GO:0030672	synaptic vesicle membrane	Otof	IDA		Mouse	MGI:MGI:3692845|PMID:17055430
Biological Process	GO:0090102	cochlea development	Otof	IEP		Rat	PMID:17229086|RGD:2316502
Biological Process	GO:0050885	neuromuscular process controlling balance	otofa	IGI	ZFIN:ZDB-MRPHLNO-150508-4,ZFIN:ZDB-MRPHLNO-150508-5	Zfish	PMID:25582200
Biological Process	GO:0050885	neuromuscular process controlling balance	otofb	IGI	ZFIN:ZDB-MRPHLNO-150508-4,ZFIN:ZDB-MRPHLNO-150508-5	Zfish	PMID:25582200
Biological Process	GO:0010996	response to auditory stimulus	otofa	IGI	ZFIN:ZDB-MRPHLNO-150508-4,ZFIN:ZDB-MRPHLNO-150508-5	Zfish	PMID:25582200
Biological Process	GO:0010996	response to auditory stimulus	otofb	IGI	ZFIN:ZDB-MRPHLNO-150508-4,ZFIN:ZDB-MRPHLNO-150508-5	Zfish	PMID:25582200
Biological Process	GO:0007605	sensory perception of sound	otofa	IDA		Zfish	PMID:27458190|ZFIN:ZDB-PUB-160728-13
Biological Process	GO:0001964	startle response	otofa	IDA		Zfish	PMID:27458190|ZFIN:ZDB-PUB-160728-13
Biological Process	GO:0016079	synaptic vesicle exocytosis	Otof	IDA		Mouse	MGI:MGI:3774237|PMID:18287496
Biological Process	GO:0016079	synaptic vesicle exocytosis	Otof	IMP		Mouse	MGI:MGI:3692845|PMID:17055430
Biological Process	GO:0016079	synaptic vesicle exocytosis	Otof	IMP	MGI:MGI:4950055	Mouse	PMID:25609709
Biological Process	GO:0016082	synaptic vesicle priming	Otof	IMP		Mouse	MGI:MGI:4461353|PMID:20562868
Biological Process	GO:0036465	synaptic vesicle recycling	otofa	IGI	ZFIN:ZDB-MRPHLNO-150508-4,ZFIN:ZDB-MRPHLNO-150508-5	Zfish	PMID:31582816
Biological Process	GO:0036465	synaptic vesicle recycling	otofb	IGI	ZFIN:ZDB-MRPHLNO-150508-4,ZFIN:ZDB-MRPHLNO-150508-5	Zfish	PMID:31582816

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern