Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes OAS1
  • Mouse genes Oas1a
  • Rat genes Oas1a,Oas1g,Oas1i
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Oas1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001730	2'-5'-oligoadenylate synthetase activity	OAS1	IDA		Human	PMID:12799444
Molecular Function	GO:0001730	2'-5'-oligoadenylate synthetase activity	OAS1	IDA		Human	PMID:2434505
Molecular Function	GO:0001730	2'-5'-oligoadenylate synthetase activity	OAS1	IDA		Human	PMID:25275129
Molecular Function	GO:0001730	2'-5'-oligoadenylate synthetase activity	Oas1a	IDA		Mouse	MGI:MGI:5285142|PMID:21056894
Molecular Function	GO:0001730	2'-5'-oligoadenylate synthetase activity	Oas1a	IDA		Mouse	PMID:12396720
Molecular Function	GO:0001730	2'-5'-oligoadenylate synthetase activity	Oas1a	IDA		Mouse	PMID:2171206
Molecular Function	GO:0001730	2'-5'-oligoadenylate synthetase activity	Oas1a	IDA		Mouse	PMID:15899864
Molecular Function	GO:0001730	2'-5'-oligoadenylate synthetase activity	Oas1a	IDA		Rat	PMID:7764002|RGD:631999
Molecular Function	GO:0003725	double-stranded RNA binding	OAS1	IDA		Human	PMID:12799444
Molecular Function	GO:0003725	double-stranded RNA binding	OAS1	IDA		Human	PMID:23319625
Molecular Function	GO:0003725	double-stranded RNA binding	OAS1	IDA		Human	PMID:25275129
Molecular Function	GO:0003725	double-stranded RNA binding	Oas1a	IDA		Mouse	MGI:MGI:5285142|PMID:21056894
Molecular Function	GO:0003725	double-stranded RNA binding	Oas1a	IDA		Mouse	PMID:12396720
Molecular Function	GO:0003725	double-stranded RNA binding	Oas1a	IDA		Mouse	PMID:15899864
Molecular Function	GO:0005515	protein binding	OAS1	IPI	UniProtKB:O89168	Human	PMID:15039538
Molecular Function	GO:0005515	protein binding	OAS1	IPI	UniProtKB:Q96LA8	Human	PMID:23455924
Molecular Function	GO:0005515	protein binding	OAS1	IPI	UniProtKB:O00471	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	OAS1	IPI	UniProtKB:P12814	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	OAS1	IPI	UniProtKB:P14373	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	OAS1	IPI	UniProtKB:P12814	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	OAS1	IPI	UniProtKB:P14373	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	Oas1a	IPI	UniProtKB:O89168	Mouse	MGI:MGI:5788397|PMID:15039538
Molecular Function	GO:0005515	protein binding	Oas1a	IPI	PR:Q8VI95	Mouse	PMID:15899864
Cellular Component	GO:0005737	cytoplasm	OAS1	IDA		Human	PMID:21245038
Cellular Component	GO:0005829	cytosol	OAS1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	OAS1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	OAS1	IDA		Human	PMID:2434505
Cellular Component	GO:0005634	nucleus	Oas1a	IDA		Rat	PMID:18421422|RGD:8553519
Biological Process	GO:0140374	antiviral innate immune response	OAS1	IEP		Human	PMID:25930096
Biological Process	GO:0140374	antiviral innate immune response	OAS1	IDA		Human	PMID:34581622
Biological Process	GO:0035458	cellular response to interferon-beta	OAS1	IDA		Human	PMID:2434505
Biological Process	GO:0098586	cellular response to virus	OAS1	IEP		Human	PMID:28146100
Biological Process	GO:0042742	defense response to bacterium	OAS1	IMP		Human	PMID:30822544
Biological Process	GO:0051607	defense response to virus	OAS1	IDA		Human	PMID:23196181
Biological Process	GO:0042593	glucose homeostasis	OAS1	IMP		Human	PMID:23575436
Biological Process	GO:0006006	glucose metabolic process	OAS1	IMP		Human	PMID:23575436
Biological Process	GO:0070106	interleukin-27-mediated signaling pathway	OAS1	IEP		Human	PMID:32270034
Biological Process	GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production	OAS1	IMP		Human	PMID:30078389
Biological Process	GO:0071659	negative regulation of IP-10 production	OAS1	IMP		Human	PMID:30078389
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	OAS1	IMP		Human	PMID:30078389
Biological Process	GO:0045071	negative regulation of viral genome replication	OAS1	IDA		Human	PMID:18931074
Biological Process	GO:0048525	negative regulation of viral process	Oas1a	IDA		Mouse	PMID:2171206
Biological Process	GO:0032728	positive regulation of interferon-beta production	OAS1	IMP		Human	PMID:30822544
Biological Process	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	OAS1	IMP		Human	PMID:30822544
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	OAS1	IMP		Human	PMID:30822544
Biological Process	GO:0006164	purine nucleotide biosynthetic process	Oas1a	IDA		Mouse	MGI:MGI:5287106|PMID:12396720
Biological Process	GO:0006164	purine nucleotide biosynthetic process	Oas1a	IDA		Mouse	MGI:MGI:5285142|PMID:21056894
Biological Process	GO:0060700	regulation of ribonuclease activity	OAS1	IDA		Human	PMID:25275129
Biological Process	GO:0009615	response to virus	OAS1	IDA		Human	PMID:18931074
Biological Process	GO:0043129	surfactant homeostasis	OAS1	IMP		Human	PMID:29455859
Biological Process	GO:0034138	toll-like receptor 3 signaling pathway	OAS1	IMP		Human	PMID:30078389
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway	OAS1	IMP		Human	PMID:30078389

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern