Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NPRL2
  • Mouse genes Nprl2
  • Rat genes Nprl2
  • Zfish genes nprl2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nprl2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005096	GTPase activator activity	NPRL2	IDA		Human	PMID:23723238
Molecular Function	GO:0005515	protein binding	NPRL2	IPI	UniProtKB:O15530	Human	PMID:18616680
Molecular Function	GO:0005515	protein binding	NPRL2	IPI	UniProtKB:Q12980	Human	PMID:19521502
Molecular Function	GO:0005515	protein binding	NPRL2	IPI	UniProtKB:Q12980	Human	PMID:28199315
Molecular Function	GO:0005515	protein binding	NPRL2	IPI	UniProtKB:Q12980	Human	PMID:28514442
Molecular Function	GO:0004672	protein kinase activity	NPRL2	IDA		Human	PMID:18616680
Cellular Component	GO:1990130	GATOR1 complex	NPRL2	IPI		Human	PMID:25263562
Cellular Component	GO:1990130	GATOR1 complex	NPRL2	IDA		Human	PMID:23723238
Cellular Component	GO:0005765	lysosomal membrane	NPRL2	IDA		Human	PMID:28199306
Biological Process	GO:0034198	cellular response to amino acid starvation	NPRL2	IMP		Human	PMID:23723238
Biological Process	GO:0033673	negative regulation of kinase activity	NPRL2	IDA		Human	PMID:18616680
Biological Process	GO:0032007	negative regulation of TOR signaling	NPRL2	IMP		Human	PMID:23723238

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern