Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NEK4
  • Mouse genes Nek4
  • Rat genes Nek4
  • Zfish genes nek4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nek4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030145	manganese ion binding	Nek4	IDA		Mouse	MGI:MGI:2155952|PMID:10529384
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Nek4	IDA		Mouse	MGI:MGI:2155952|PMID:10529384
Cellular Component	GO:0036064	ciliary basal body	Nek4	IDA		Rat	PMID:21685204|RGD:13204813
Cellular Component	GO:0097014	ciliary plasm	Nek4	IDA		Rat	PMID:21685204|RGD:13204813
Cellular Component	GO:0035253	ciliary rootlet	Nek4	IDA		Rat	PMID:21685204|RGD:13204813
Cellular Component	GO:0035869	ciliary transition zone	Nek4	IDA		Rat	PMID:21685204|RGD:13204813
Cellular Component	GO:0005737	cytoplasm	Nek4	IDA		Mouse	MGI:MGI:2155952|PMID:10529384
Cellular Component	GO:0005829	cytosol	NEK4	IDA		Human	GO_REF:0000052
Biological Process	GO:0006974	DNA damage response	NEK4	IMP		Human	PMID:22851694
Biological Process	GO:0000278	mitotic cell cycle	NEK4	IMP		Human	PMID:22851694
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	NEK4	IMP		Human	PMID:22851694
Biological Process	GO:0006468	protein phosphorylation	Nek4	IDA		Mouse	MGI:MGI:2155952|PMID:10529384
Biological Process	GO:2000772	regulation of cellular senescence	NEK4	IMP		Human	PMID:22851694

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern