Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NEK2
  • Mouse genes Nek2
  • Rat genes Nek2,Nek2l1
  • Zfish genes nek2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nek2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	NEK2	IPI	UniProtKB:Q9BV73	Human	PMID:10880350
Molecular Function	GO:0005515	protein binding	NEK2	IPI	UniProtKB:Q9Y6D9	Human	PMID:14978040
Molecular Function	GO:0005515	protein binding	NEK2	IPI	UniProtKB:Q8NG66	Human	PMID:15161910
Molecular Function	GO:0005515	protein binding	NEK2	IPI	UniProtKB:P30260	Human	PMID:16648845
Molecular Function	GO:0005515	protein binding	NEK2	IPI	UniProtKB:Q6GQ04	Human	PMID:16648845
Molecular Function	GO:0005515	protein binding	NEK2	IPI	UniProtKB:Q5FBB7	Human	PMID:17621308
Molecular Function	GO:0005515	protein binding	NEK2	IPI	UniProtKB:P35222	Human	PMID:18086858
Molecular Function	GO:0005515	protein binding	NEK2	IPI	UniProtKB:P36873-1	Human	PMID:21382349
Molecular Function	GO:0005515	protein binding	NEK2	IPI	UniProtKB:Q9UJX5	Human	PMID:23288039
Molecular Function	GO:0005515	protein binding	NEK2	IPI	UniProtKB:P36873-1	Human	PMID:24116158
Molecular Function	GO:0005515	protein binding	NEK2	IPI	UniProtKB:Q76N32	Human	PMID:24554434
Molecular Function	GO:0005515	protein binding	NEK2	IPI	UniProtKB:Q9NXG0	Human	PMID:24554434
Molecular Function	GO:0005515	protein binding	NEK2	IPI	UniProtKB:Q6P2H3	Human	PMID:26220856
Molecular Function	GO:0005515	protein binding	NEK2	IPI	UniProtKB:Q5T7B8	Human	PMID:26290419
Molecular Function	GO:0005515	protein binding	NEK2	IPI	UniProtKB:Q68D86	Human	PMID:30404835
Molecular Function	GO:0005515	protein binding	NEK2	IPI	UniProtKB:Q9BV73	Human	PMID:9647649
Molecular Function	GO:0005515	protein binding	Nek2	IPI	PR:Q9D6J4	Mouse	PMID:14697346
Molecular Function	GO:0005515	protein binding	Nek2	IPI	PR:P52927	Mouse	PMID:14668482
Molecular Function	GO:0004672	protein kinase activity	NEK2	IDA		Human	PMID:10880350
Molecular Function	GO:0004672	protein kinase activity	NEK2	IDA		Human	PMID:18086858
Molecular Function	GO:0004672	protein kinase activity	NEK2	IMP		Human	PMID:24554434
Molecular Function	GO:0004672	protein kinase activity	NEK2	IDA		Human	PMID:26220856
Molecular Function	GO:0004672	protein kinase activity	Nek2	IDA		Mouse	PMID:14668482
Molecular Function	GO:0004672	protein kinase activity	Nek2	IDA		Mouse	PMID:14697346
Molecular Function	GO:0019903	protein phosphatase binding	NEK2	IPI	UniProtKB:P36873	Human	PMID:10880350
Cellular Component	GO:0005813	centrosome	NEK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005813	centrosome	NEK2	IDA		Human	PMID:21399614
Cellular Component	GO:0005813	centrosome	NEK2	IDA		Human	PMID:26220856
Cellular Component	GO:0000794	condensed nuclear chromosome	Nek2	IDA		Mouse	PMID:15479717
Cellular Component	GO:0000776	kinetochore	NEK2	IDA		Human	PMID:17621308
Cellular Component	GO:0000776	kinetochore	NEK2	IDA		Human	PMID:14978040
Cellular Component	GO:0030496	midbody	Nek2	IDA		Mouse	PMID:15479717
Cellular Component	GO:0005654	nucleoplasm	NEK2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0032991	protein-containing complex	NEK2	IMP		Human	PMID:10880350
Cellular Component	GO:0000922	spindle pole	Nek2	IDA		Mouse	PMID:15479717
Biological Process	GO:0001824	blastocyst development	Nek2	IMP		Mouse	PMID:19117032
Biological Process	GO:0051299	centrosome separation	NEK2	IDA		Human	PMID:18086858
Biological Process	GO:0007059	chromosome segregation	NEK2	IDA		Human	PMID:14978040
Biological Process	GO:0007059	chromosome segregation	Nek2	IMP		Mouse	PMID:19117032
Biological Process	GO:0000070	mitotic sister chromatid segregation	Nek2	IMP		Mouse	PMID:15479717
Biological Process	GO:0090307	mitotic spindle assembly	Nek2	IMP		Mouse	PMID:19117032
Biological Process	GO:1903126	negative regulation of centriole-centriole cohesion	NEK2	IMP		Human	PMID:24554434
Biological Process	GO:0043392	negative regulation of DNA binding	Nek2	IDA		Mouse	PMID:14668482
Biological Process	GO:0051973	positive regulation of telomerase activity	NEK2	IMP		Human	PMID:21531765
Biological Process	GO:1904355	positive regulation of telomere capping	NEK2	IMP		Human	PMID:21531765
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	NEK2	IMP		Human	PMID:21531765
Biological Process	GO:0046777	protein autophosphorylation	NEK2	IMP		Human	PMID:10880350
Biological Process	GO:0046777	protein autophosphorylation	NEK2	IDA		Human	PMID:17626005
Biological Process	GO:0006468	protein phosphorylation	NEK2	IDA		Human	PMID:21076410
Biological Process	GO:0006468	protein phosphorylation	NEK2	IMP		Human	PMID:24554434
Biological Process	GO:0006468	protein phosphorylation	Nek2	IDA		Mouse	PMID:14697346
Biological Process	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	NEK2	IMP		Human	PMID:18297113
Biological Process	GO:0046602	regulation of mitotic centrosome separation	NEK2	IMP		Human	PMID:26220856
Biological Process	GO:0046548	retinal rod cell development	nek2	IMP	ZFIN:ZDB-MRPHLNO-131126-3	Zfish	PMID:24043777
Biological Process	GO:0046548	retinal rod cell development	nek2	IGI	ZFIN:ZDB-MRPHLNO-100326-1,ZFIN:ZDB-MRPHLNO-131126-3	Zfish	PMID:24043777

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern