Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MYL4
  • Mouse genes Myl4
  • Rat genes Myl4
  • Zfish genes cmlc1,myl4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Myl4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	MYL4	IMP		Human	PMID:9738905
Molecular Function	GO:0003785	actin monomer binding	MYL4	IDA		Human	PMID:9180271
Cellular Component	GO:0031672	A band	MYL4	IMP		Human	PMID:14985854
Biological Process	GO:0060048	cardiac muscle contraction	MYL4	IMP		Human	PMID:14985854
Biological Process	GO:0060048	cardiac muscle contraction	MYL4	IMP		Human	PMID:16675844
Biological Process	GO:0048738	cardiac muscle tissue development	cmlc1	IMP	ZFIN:ZDB-MRPHLNO-081229-5	Zfish	PMID:18343897
Biological Process	GO:0060047	heart contraction	cmlc1	IMP	ZFIN:ZDB-GENO-090527-1	Zfish	PMID:19168438
Biological Process	GO:0060047	heart contraction	cmlc1	IMP	ZFIN:ZDB-MRPHLNO-081229-5	Zfish	PMID:18343897
Biological Process	GO:0003007	heart morphogenesis	cmlc1	IMP	ZFIN:ZDB-GENO-090527-1	Zfish	PMID:19168438
Biological Process	GO:0032781	positive regulation of ATP-dependent activity	MYL4	IMP		Human	PMID:9738905
Biological Process	GO:0002026	regulation of the force of heart contraction	MYL4	IMP		Human	PMID:16675844
Biological Process	GO:0045214	sarcomere organization	cmlc1	IMP	ZFIN:ZDB-MRPHLNO-081229-5	Zfish	PMID:18343897
Biological Process	GO:0055015	ventricular cardiac muscle cell development	cmlc1	IMP	ZFIN:ZDB-MRPHLNO-081229-5	Zfish	PMID:18343897
Biological Process	GO:0055005	ventricular cardiac myofibril assembly	cmlc1	IMP	ZFIN:ZDB-MRPHLNO-090527-1	Zfish	PMID:19168438

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern