Comparative GO Graph (mouse, human)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MUC16
  • Mouse genes Muc16
  • Rat genes
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Muc16

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	MUC16	IPI	UniProtKB:Q13421	Human	PMID:14676194
Cellular Component	GO:0009897	external side of plasma membrane	Muc16	IDA		Mouse	PMID:18637025
Cellular Component	GO:0070062	extracellular exosome	MUC16	HDA		Human	PMID:19199708
Cellular Component	GO:0019898	extrinsic component of membrane	MUC16	IDA		Human	PMID:12766047
Cellular Component	GO:0031982	vesicle	MUC16	HDA		Human	PMID:19190083
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	Muc16	IMP	MGI:MGI:3840843	Mouse	PMID:24812549
Biological Process	GO:0032715	negative regulation of interleukin-6 production	Muc16	IMP	MGI:MGI:3840843	Mouse	PMID:24812549
Biological Process	GO:0061045	negative regulation of wound healing	Muc16	IMP	MGI:MGI:3840843	Mouse	PMID:24812549

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern