Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MLH3
  • Mouse genes Mlh3
  • Rat genes Mlh3
  • Zfish genes mlh3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mlh3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019237	centromeric DNA binding	Mlh3	IDA		Mouse	PMID:16260499
Molecular Function	GO:0003682	chromatin binding	Mlh3	IDA		Mouse	PMID:12091911
Molecular Function	GO:0005515	protein binding	MLH3	IPI	UniProtKB:P40692	Human	PMID:11292842
Molecular Function	GO:0005515	protein binding	MLH3	IPI	UniProtKB:Q9Y2M0	Human	PMID:20603073
Molecular Function	GO:0005515	protein binding	MLH3	IPI	UniProtKB:P40692	Human	PMID:27229929
Cellular Component	GO:0005712	chiasma	Mlh3	IDA		Mouse	PMID:12091911
Cellular Component	GO:0005712	chiasma	Mlh3	IDA		Mouse	PMID:17696610
Cellular Component	GO:0000793	condensed chromosome	Mlh3	IDA		Mouse	PMID:12091911
Cellular Component	GO:0000794	condensed nuclear chromosome	Mlh3	IDA		Mouse	PMID:24891606
Cellular Component	GO:0001673	male germ cell nucleus	Mlh3	IDA		Mouse	PMID:17696610
Cellular Component	GO:0032300	mismatch repair complex	Mlh3	IDA		Mouse	PMID:22164254
Cellular Component	GO:0005654	nucleoplasm	MLH3	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000795	synaptonemal complex	Mlh3	IDA		Mouse	PMID:16260499
Cellular Component	GO:0000795	synaptonemal complex	Mlh3	IDA		Mouse	PMID:15467367
Biological Process	GO:0006974	DNA damage response	Mlh3	IGI	MGI:MGI:104288	Mouse	PMID:16204034
Biological Process	GO:0006974	DNA damage response	Mlh3	IMP	MGI:MGI:2384218	Mouse	PMID:16204034
Biological Process	GO:0007144	female meiosis I	Mlh3	IMP	MGI:MGI:2384218	Mouse	PMID:12091911
Biological Process	GO:0007140	male meiotic nuclear division	Mlh3	IMP	MGI:MGI:2384218	Mouse	PMID:12091911
Biological Process	GO:0007140	male meiotic nuclear division	Mlh3	IMP		Mouse	PMID:15467367
Biological Process	GO:0006298	mismatch repair	Mlh3	IGI	MGI:MGI:104288	Mouse	PMID:16204034
Biological Process	GO:0006298	mismatch repair	Mlh3	IMP	MGI:MGI:2384218	Mouse	PMID:16204034
Biological Process	GO:0008104	protein localization	Mlh3	IMP	MGI:MGI:2384218	Mouse	PMID:16260499
Biological Process	GO:0007130	synaptonemal complex assembly	Mlh3	IMP	MGI:MGI:2384218	Mouse	PMID:16260499

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern