Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes METTL23
  • Mouse genes Mettl23
  • Rat genes Mettl23
  • Zfish genes mettl23
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mettl23

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140297	DNA-binding transcription factor binding	METTL23	IPI	UniProtKB:Q06546	Human	PMID:24501276
Molecular Function	GO:0031072	heat shock protein binding	METTL23	IPI	UniProtKB:P11021	Human	PMID:23349634
Molecular Function	GO:0031072	heat shock protein binding	METTL23	IPI	UniProtKB:P14625	Human	PMID:23349634
Molecular Function	GO:0035642	histone H3R17 methyltransferase activity	Mettl23	IDA		Mouse	MGI:MGI:6103984|PMID:28930672
Molecular Function	GO:0005515	protein binding	METTL23	IPI	UniProtKB:Q9NYU1	Human	PMID:23349634
Molecular Function	GO:0005515	protein binding	METTL23	IPI	UniProtKB:Q9NYU2	Human	PMID:23349634
Molecular Function	GO:0005515	protein binding	Mettl23	IPI	UniProtKB:Q8BG87|UniProtKB:Q9DAG5	Mouse	MGI:MGI:6103984|PMID:28930672
Cellular Component	GO:0005737	cytoplasm	METTL23	IDA		Human	PMID:23349634
Cellular Component	GO:0005737	cytoplasm	METTL23	IDA		Human	PMID:24501276
Cellular Component	GO:0005737	cytoplasm	Mettl23	IDA		Mouse	MGI:MGI:6103984|PMID:28930672
Cellular Component	GO:0001939	female pronucleus	Mettl23	IDA		Mouse	MGI:MGI:6103984|PMID:28930672
Cellular Component	GO:0001940	male pronucleus	Mettl23	IDA		Mouse	MGI:MGI:6103984|PMID:28930672
Cellular Component	GO:0005634	nucleus	METTL23	IDA		Human	PMID:24501276
Cellular Component	GO:0032991	protein-containing complex	METTL23	IDA		Human	PMID:23349634
Biological Process	GO:0044725	chromatin reprogramming in the zygote	Mettl23	IMP		Mouse	MGI:MGI:6103984|PMID:28930672
Biological Process	GO:0050890	cognition	METTL23	IMP		Human	PMID:24501276
Biological Process	GO:0044727	DNA demethylation of male pronucleus	Mettl23	IMP		Mouse	MGI:MGI:6103984|PMID:28930672
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	METTL23	IMP		Human	PMID:24501276

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern