Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MDH1
  • Mouse genes Mdh1
  • Rat genes Mdh1
  • Zfish genes mdh1aa,mdh1ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mdh1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030060	L-malate dehydrogenase activity	MDH1	EXP		Human	PMID:3052244
Molecular Function	GO:0030060	L-malate dehydrogenase activity	Mdh1	IMP	MGI:MGI:1933639	Mouse	PMID:7698769
Molecular Function	GO:0030060	L-malate dehydrogenase activity	Mdh1	IDA		Rat	PMID:12351438|RGD:2303499
Molecular Function	GO:0030060	L-malate dehydrogenase activity	Mdh1	IDA		Rat	PMID:17447164|RGD:1624966
Molecular Function	GO:0016615	malate dehydrogenase activity	Mdh1	IDA		Rat	PMID:2820961|RGD:724435
Molecular Function	GO:0051287	NAD binding	Mdh1	IDA		Rat	PMID:17447164|RGD:1624966
Molecular Function	GO:0005515	protein binding	MDH1	IPI	UniProtKB:P54274	Human	PMID:21044950
Cellular Component	GO:0005813	centrosome	MDH1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005737	cytoplasm	MDH1	IDA		Human	PMID:34547241
Cellular Component	GO:0005829	cytosol	MDH1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	MDH1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	MDH1	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	MDH1	HDA		Human	PMID:22664934
Cellular Component	GO:0005739	mitochondrion	Mdh1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0043209	myelin sheath	Mdh1	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Biological Process	GO:0006108	malate metabolic process	Mdh1	IDA		Rat	PMID:12351438|RGD:2303499
Biological Process	GO:0006108	malate metabolic process	Mdh1	IDA		Rat	PMID:17447164|RGD:1624966
Biological Process	GO:0019674	NAD metabolic process	Mdh1	IDA		Rat	PMID:17447164|RGD:1624966
Biological Process	GO:0006734	NADH metabolic process	MDH1	IDA		Human	PMID:34547241
Biological Process	GO:0006734	NADH metabolic process	Mdh1	IDA		Rat	PMID:12351438|RGD:2303499
Biological Process	GO:0006739	NADP metabolic process	MDH1	IDA		Human	PMID:34547241
Biological Process	GO:0006107	oxaloacetate metabolic process	Mdh1	IDA		Rat	PMID:17447164|RGD:1624966

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern