Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MC4R
  • Mouse genes Mc4r
  • Rat genes Mc4r
  • Zfish genes mc4r
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mc4r

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042562	hormone binding	Mc4r	IDA		Rat	PMID:21527895|RGD:6478803
Molecular Function	GO:0004977	melanocortin receptor activity	Mc4r	IDA		Mouse	PMID:9454589
Molecular Function	GO:0004977	melanocortin receptor activity	Mc4r	IDA		Rat	PMID:17023527|RGD:1600765
Molecular Function	GO:0004977	melanocortin receptor activity	Mc4r	IMP		Rat	PMID:17023527|RGD:1600765
Molecular Function	GO:0004977	melanocortin receptor activity	mc4r	IDA		Zfish	PMID:23869017|ZFIN:ZDB-PUB-130805-10
Molecular Function	GO:0004980	melanocyte-stimulating hormone receptor activity	MC4R	IDA		Human	PMID:14764818
Molecular Function	GO:0004980	melanocyte-stimulating hormone receptor activity	MC4R	IPI	UniProtKB:P01189	Human	PMID:19743876
Molecular Function	GO:0004980	melanocyte-stimulating hormone receptor activity	Mc4r	IDA		Mouse	PMID:9454589
Molecular Function	GO:0042923	neuropeptide binding	MC4R	IMP		Human	PMID:15927146
Molecular Function	GO:0017046	peptide hormone binding	Mc4r	IDA		Rat	PMID:17023527|RGD:1600765
Molecular Function	GO:0017046	peptide hormone binding	Mc4r	IMP		Rat	PMID:17023527|RGD:1600765
Molecular Function	GO:0005515	protein binding	MC4R	IPI	UniProtKB:Q8TCY5	Human	PMID:19329486
Molecular Function	GO:0005515	protein binding	MC4R	IPI	UniProtKB:Q96G30	Human	PMID:19329486
Molecular Function	GO:0005515	protein binding	MC4R	IPI	UniProtKB:P01189	Human	PMID:19743876
Molecular Function	GO:0005515	protein binding	MC4R	IPI	UniProtKB:P25686-3	Human	PMID:21719532
Molecular Function	GO:0005515	protein binding	Mc4r	IPI	PR:Q6A051	Mouse	PMID:14531729
Molecular Function	GO:0005515	protein binding	Mc4r	IPI	PR:Q03288	Mouse	PMID:9454589
Molecular Function	GO:0031625	ubiquitin protein ligase binding	MC4R	IPI	UniProtKB:O60291	Human	PMID:19737927
Cellular Component	GO:0005634	nucleus	Mc4r	IDA		Rat	PMID:22183812|RGD:6484138
Cellular Component	GO:0005886	plasma membrane	Mc4r	IDA		Rat	PMID:20531371|RGD:13825198
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	MC4R	IDA		Human	PMID:19329486
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	MC4R	IDA		Human	PMID:19743876
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	mc4r	IDA		Zfish	PMID:23869017
Biological Process	GO:0002024	diet induced thermogenesis	Mc4r	IDA		Rat	PMID:14988515|RGD:1600780
Biological Process	GO:0097009	energy homeostasis	mc4r	IDA		Zfish	PMID:23869017|ZFIN:ZDB-PUB-130805-10
Biological Process	GO:0006112	energy reserve metabolic process	Mc4r	IDA		Rat	PMID:14988515|RGD:1600780
Biological Process	GO:0006112	energy reserve metabolic process	mc4r	IDA		Zfish	PMID:23869017|ZFIN:ZDB-PUB-130805-10
Biological Process	GO:0007631	feeding behavior	Mc4r	IMP	MGI:MGI:2183586	Mouse	PMID:12796784
Biological Process	GO:0007631	feeding behavior	Mc4r	IDA		Rat	PMID:14988515|RGD:1600780
Biological Process	GO:0030073	insulin secretion	Mc4r	IGI	MGI:MGI:1343180	Mouse	PMID:16141392
Biological Process	GO:2000252	negative regulation of feeding behavior	Mc4r	IMP		Rat	PMID:20118207|RGD:6484232
Biological Process	GO:2000252	negative regulation of feeding behavior	mc4r	IMP	ZFIN:ZDB-MRPHLNO-130312-7	Zfish	PMID:23300705
Biological Process	GO:2000252	negative regulation of feeding behavior	mc4r	IMP	ZFIN:ZDB-MRPHLNO-130312-8	Zfish	PMID:23300705
Biological Process	GO:0045780	positive regulation of bone resorption	MC4R	IMP		Human	PMID:16614075
Biological Process	GO:0045780	positive regulation of bone resorption	Mc4r	IMP		Mouse	MGI:MGI:3696590|PMID:16614075
Biological Process	GO:1903998	regulation of eating behavior	Mc4r	IMP		Mouse	MGI:MGI:6716959|PMID:25096581
Biological Process	GO:0060259	regulation of feeding behavior	Mc4r	IMP		Rat	PMID:21527895|RGD:6478803
Biological Process	GO:2000821	regulation of grooming behavior	Mc4r	IMP		Rat	PMID:21527895|RGD:6478803
Biological Process	GO:0040008	regulation of growth	mc4r	IGI	ZFIN:ZDB-GENO-130226-3,ZFIN:ZDB-MRPHLNO-130913-2	Zfish	PMID:23869017
Biological Process	GO:0040008	regulation of growth	mc4r	IGI	ZFIN:ZDB-GENO-130226-3,ZFIN:ZDB-MRPHLNO-130913-3	Zfish	PMID:23869017
Biological Process	GO:0040008	regulation of growth	mc4r	IGI	ZFIN:ZDB-GENO-130226-3,ZFIN:ZDB-MRPHLNO-130226-1	Zfish	PMID:22245570
Biological Process	GO:0019222	regulation of metabolic process	Mc4r	IMP	MGI:MGI:2183586	Mouse	PMID:12796784
Biological Process	GO:0032868	response to insulin	Mc4r	IMP	MGI:MGI:2183586	Mouse	PMID:16141392
Biological Process	GO:1990680	response to melanocyte-stimulating hormone	Mc4r	IMP		Mouse	MGI:MGI:6716959|PMID:25096581

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern