Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MC2R
  • Mouse genes Mc2r
  • Rat genes Mc2r
  • Zfish genes mc2r
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mc2r

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004978	corticotropin receptor activity	mc2r	IDA		Zfish	PMID:20138960
Molecular Function	GO:0005515	protein binding	MC2R	IPI	UniProtKB:Q8TCY5	Human	PMID:18077336
Molecular Function	GO:0005515	protein binding	MC2R	IPI	UniProtKB:Q8TCY5-1	Human	PMID:18840636
Molecular Function	GO:0005515	protein binding	MC2R	IPI	UniProtKB:Q8TCY5-1	Human	PMID:19151134
Molecular Function	GO:0005515	protein binding	MC2R	IPI	UniProtKB:Q8TCY5	Human	PMID:19329486
Molecular Function	GO:0005515	protein binding	MC2R	IPI	UniProtKB:Q96G30	Human	PMID:19329486
Molecular Function	GO:0005515	protein binding	MC2R	IPI	UniProtKB:Q8TCY5	Human	PMID:28298427
Molecular Function	GO:0005515	protein binding	MC2R	IPI	UniProtKB:Q96G30	Human	PMID:28298427
Cellular Component	GO:0005737	cytoplasm	Mc2r	IDA		Rat	PMID:15781985|RGD:5508710
Cellular Component	GO:0005737	cytoplasm	mc2r	IDA		Zfish	PMID:20138960
Cellular Component	GO:0005886	plasma membrane	Mc2r	IDA		Rat	PMID:15781985|RGD:5508710
Cellular Component	GO:0005886	plasma membrane	mc2r	IDA		Zfish	PMID:20138960
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	MC2R	IDA		Human	PMID:19329486
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	mc2r	IDA		Zfish	PMID:20138960
Biological Process	GO:0030325	adrenal gland development	mc2r	IMP	ZFIN:ZDB-MRPHLNO-070524-1	Zfish	PMID:17082325
Biological Process	GO:0033555	multicellular organismal response to stress	mc2r	IEP		Zfish	PMID:25748166
Biological Process	GO:0001890	placenta development	Mc2r	IEP		Rat	PMID:15781985|RGD:5508710

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern