Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MBD4
  • Mouse genes Mbd4
  • Rat genes Mbd4
  • Zfish genes mbd4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mbd4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Mbd4	IDA		Mouse	PMID:9774669
Molecular Function	GO:0005515	protein binding	MBD4	IPI	UniProtKB:Q13158	Human	PMID:12702765
Molecular Function	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity	MBD4	IDA		Human	PMID:14614141
Cellular Component	GO:0000785	chromatin	Mbd4	IDA		Mouse	PMID:9774669
Cellular Component	GO:0005737	cytoplasm	Mbd4	IDA		Mouse	PMID:17546630
Cellular Component	GO:0016607	nuclear speck	MBD4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Mbd4	IDA		Mouse	PMID:17546630
Cellular Component	GO:0005634	nucleus	Mbd4	IDA		Mouse	PMID:9774669
Biological Process	GO:0006974	DNA damage response	Mbd4	IMP	MGI:MGI:2183491	Mouse	PMID:14562041
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	Mbd4	IMP	MGI:MGI:2183491	Mouse	PMID:14562041
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	Mbd4	IMP	MGI:MGI:2684310	Mouse	PMID:14614141
Biological Process	GO:0032355	response to estradiol	Mbd4	IEP		Rat	PMID:22109888|RGD:9588666
Biological Process	GO:0009314	response to radiation	Mbd4	IMP	MGI:MGI:2183491	Mouse	PMID:14562041

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern