Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAT1A
  • Mouse genes Mat1a
  • Rat genes Mat1a
  • Zfish genes mat1a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mat1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0043531	ADP binding	Mat1a	IDA		Rat	PMID:12888348|RGD:1599916
Molecular Function	GO:0016597	amino acid binding	Mat1a	IDA		Rat	PMID:10873471|RGD:7242772
Molecular Function	GO:0016597	amino acid binding	Mat1a	IDA		Rat	PMID:12888348|RGD:1599916
Molecular Function	GO:0005524	ATP binding	Mat1a	IDA		Rat	PMID:10873471|RGD:7242772
Molecular Function	GO:0005524	ATP binding	Mat1a	IDA		Rat	PMID:12888348|RGD:1599916
Molecular Function	GO:0042802	identical protein binding	MAT1A	IPI	UniProtKB:Q00266	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	MAT1A	IPI	UniProtKB:Q00266	Human	PMID:32296183
Molecular Function	GO:0042802	identical protein binding	Mat1a	IPI	RGD:3050	Rat	PMID:10873471|RGD:7242772
Molecular Function	GO:0042802	identical protein binding	Mat1a	IPI	RGD:3050	Rat	PMID:19497982|RGD:7242770
Molecular Function	GO:0042802	identical protein binding	Mat1a	IPI	RGD:3050	Rat	PMID:9202427|RGD:1359039
Molecular Function	GO:0042802	identical protein binding	Mat1a	IPI	UniProtKB:P13444	Rat	PMID:9202427|RGD:1359039
Molecular Function	GO:0000287	magnesium ion binding	Mat1a	IDA		Rat	PMID:12888348|RGD:1599916
Molecular Function	GO:0004478	methionine adenosyltransferase activity	MAT1A	IDA		Human	PMID:10677294
Molecular Function	GO:0004478	methionine adenosyltransferase activity	Mat1a	IDA		Rat	PMID:10898761|RGD:7242777
Molecular Function	GO:0004478	methionine adenosyltransferase activity	Mat1a	IDA		Rat	PMID:19497982|RGD:7242770
Molecular Function	GO:0004478	methionine adenosyltransferase activity	Mat1a	IDA		Rat	PMID:9202427|RGD:1359039
Molecular Function	GO:0005515	protein binding	MAT1A	IPI	UniProtKB:P31153	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MAT1A	IPI	UniProtKB:P31153	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAT1A	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAT1A	IPI	UniProtKB:P42858	Human	PMID:32814053
Cellular Component	GO:0005829	cytosol	Mat1a	IDA		Rat	PMID:10898761|RGD:7242777
Cellular Component	GO:0005829	cytosol	Mat1a	IDA		Rat	PMID:19239903|RGD:7242903
Cellular Component	GO:0005829	cytosol	Mat1a	IDA		Rat	PMID:19497982|RGD:7242770
Cellular Component	GO:0048269	methionine adenosyltransferase complex	MAT1A	IPI		Human	PMID:25075345
Cellular Component	GO:0016363	nuclear matrix	Mat1a	IDA		Rat	PMID:19497982|RGD:7242770
Biological Process	GO:0009087	methionine catabolic process	MAT1A	IMP		Human	PMID:10677294
Biological Process	GO:0051289	protein homotetramerization	MAT1A	IDA		Human	PMID:23425511
Biological Process	GO:0065003	protein-containing complex assembly	Mat1a	IDA		Rat	PMID:10873471|RGD:7242772
Biological Process	GO:0065003	protein-containing complex assembly	Mat1a	IDA		Rat	PMID:19497982|RGD:7242770
Biological Process	GO:0065003	protein-containing complex assembly	Mat1a	IDA		Rat	PMID:9202427|RGD:1359039
Biological Process	GO:0006556	S-adenosylmethionine biosynthetic process	MAT1A	IMP		Human	PMID:10677294
Biological Process	GO:0006556	S-adenosylmethionine biosynthetic process	MAT1A	IDA		Human	PMID:25075345
Biological Process	GO:0006556	S-adenosylmethionine biosynthetic process	Mat1a	IDA		Rat	PMID:10898761|RGD:7242777
Biological Process	GO:0006556	S-adenosylmethionine biosynthetic process	Mat1a	IDA		Rat	PMID:19497982|RGD:7242770
Biological Process	GO:0006556	S-adenosylmethionine biosynthetic process	Mat1a	IDA		Rat	PMID:9202427|RGD:1359039

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern