Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MARCHF6
  • Mouse genes Marchf6
  • Rat genes Marchf6
  • Zfish genes marchf6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Marchf6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	MARCHF6	IPI	UniProtKB:Q92813	Human	PMID:19651899
Molecular Function	GO:0005515	protein binding	MARCHF6	IPI	UniProtKB:P41220-1	Human	PMID:25766235
Molecular Function	GO:0005515	protein binding	MARCHF6	IPI	UniProtKB:Q9UHX3	Human	PMID:32296183
Molecular Function	GO:0031624	ubiquitin conjugating enzyme binding	MARCHF6	IPI	UniProtKB:P62253	Human	PMID:15673284
Molecular Function	GO:0061630	ubiquitin protein ligase activity	MARCHF6	IDA		Human	PMID:24449766
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	MARCHF6	IDA		Human	PMID:15673284
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	MARCHF6	IMP		Human	PMID:19651899
Molecular Function	GO:1990381	ubiquitin-specific protease binding	MARCHF6	IPI	UniProtKB:Q3UJD6	Human	PMID:25088257
Cellular Component	GO:0005783	endoplasmic reticulum	MARCHF6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005789	endoplasmic reticulum membrane	MARCHF6	IDA		Human	PMID:15673284
Cellular Component	GO:0016020	membrane	MARCHF6	IDA		Human	PMID:16373356
Cellular Component	GO:0016020	membrane	MARCHF6	HDA		Human	PMID:19946888
Biological Process	GO:0010498	proteasomal protein catabolic process	MARCHF6	IDA		Human	PMID:15673284
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	MARCHF6	IDA		Human	PMID:24449766
Biological Process	GO:0070936	protein K48-linked ubiquitination	MARCHF6	IDA		Human	PMID:15673284
Biological Process	GO:0016567	protein ubiquitination	MARCHF6	IDA		Human	PMID:24449766

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern