Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAP4K2
  • Mouse genes Map4k2
  • Rat genes Map4k2
  • Zfish genes map4k2,map4k6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Map4k2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	MAP4K2	IDA		Human	PMID:11784851
Molecular Function	GO:0031435	mitogen-activated protein kinase kinase kinase binding	MAP4K2	IPI	UniProtKB:Q16584	Human	PMID:17584736
Molecular Function	GO:0005515	protein binding	MAP4K2	IPI	UniProtKB:Q13233	Human	PMID:11784851
Molecular Function	GO:0005515	protein binding	MAP4K2	IPI	UniProtKB:Q9NUX5	Human	PMID:21044950
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MAP4K2	IDA		Human	PMID:11784851
Biological Process	GO:0035556	intracellular signal transduction	MAP4K2	IDA		Human	PMID:11784851
Biological Process	GO:0046330	positive regulation of JNK cascade	MAP4K2	IDA		Human	PMID:17584736
Biological Process	GO:0043507	positive regulation of JUN kinase activity	MAP4K2	IDA		Human	PMID:17584736
Biological Process	GO:0006468	protein phosphorylation	MAP4K2	IDA		Human	PMID:11784851
Biological Process	GO:0006903	vesicle targeting	Map4k2	IDA		Mouse	MGI:MGI:83726|PMID:8643544

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern