Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LRRC8D
  • Mouse genes Lrrc8d
  • Rat genes Lrrc8d
  • Zfish genes lrrc8da,lrrc8db
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lrrc8d

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	LRRC8D	IPI	UniProtKB:Q8IWT6	Human	PMID:24790029
Molecular Function	GO:0005225	volume-sensitive anion channel activity	LRRC8D	IMP		Human	PMID:28193731
Molecular Function	GO:0005225	volume-sensitive anion channel activity	LRRC8D	IMP		Human	PMID:26824658
Molecular Function	GO:0005225	volume-sensitive anion channel activity	LRRC8D	IDA		Human	PMID:32415200
Molecular Function	GO:0005225	volume-sensitive anion channel activity	Lrrc8d	IMP		Mouse	MGI:MGI:6160993|PMID:29773801
Molecular Function	GO:0005225	volume-sensitive anion channel activity	Lrrc8d	IMP		Rat	PMID:28833202|RGD:13673739
Cellular Component	GO:0005737	cytoplasm	LRRC8D	IDA		Human	PMID:24790029
Cellular Component	GO:0016020	membrane	LRRC8D	HDA		Human	PMID:19946888
Cellular Component	GO:0016020	membrane	LRRC8D	IDA		Human	PMID:32415200
Cellular Component	GO:0034702	monoatomic ion channel complex	LRRC8D	IMP		Human	PMID:28193731
Cellular Component	GO:0034702	monoatomic ion channel complex	Lrrc8d	IMP		Rat	PMID:28833202|RGD:13673739
Cellular Component	GO:0005886	plasma membrane	LRRC8D	IDA		Human	PMID:24790029
Cellular Component	GO:0005886	plasma membrane	LRRC8D	IMP		Human	PMID:26824658
Cellular Component	GO:0005886	plasma membrane	LRRC8D	IMP		Human	PMID:28193731
Cellular Component	GO:0005886	plasma membrane	Lrrc8d	IDA		Mouse	MGI:MGI:6160993|PMID:29773801
Biological Process	GO:0015810	aspartate transmembrane transport	LRRC8D	IMP		Human	PMID:28193731
Biological Process	GO:0015810	aspartate transmembrane transport	Lrrc8d	IMP		Rat	PMID:28833202|RGD:13673739
Biological Process	GO:0071470	cellular response to osmotic stress	LRRC8D	IMP		Human	PMID:28193731
Biological Process	GO:0071470	cellular response to osmotic stress	Lrrc8d	IMP		Rat	PMID:28833202|RGD:13673739
Biological Process	GO:0001678	intracellular glucose homeostasis	Lrrc8d	IMP		Mouse	MGI:MGI:6160993|PMID:29773801
Biological Process	GO:0098656	monoatomic anion transmembrane transport	LRRC8D	IMP		Human	PMID:24790029
Biological Process	GO:0098656	monoatomic anion transmembrane transport	LRRC8D	IDA		Human	PMID:32415200
Biological Process	GO:0034214	protein hexamerization	LRRC8D	IDA		Human	PMID:32415200
Biological Process	GO:0015734	taurine transport	LRRC8D	IMP		Human	PMID:28193731
Biological Process	GO:0015734	taurine transport	Lrrc8d	IMP		Rat	PMID:28833202|RGD:13673739

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern