Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LIMK2
  • Mouse genes Limk2
  • Rat genes Limk2
  • Zfish genes limk2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Limk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	LIMK2	IPI	UniProtKB:O94811	Human	PMID:22328514
Molecular Function	GO:0005515	protein binding	LIMK2	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	LIMK2	IPI	UniProtKB:Q16543	Human	PMID:25036637
Molecular Function	GO:0005515	protein binding	LIMK2	IPI	UniProtKB:P08238	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	LIMK2	IPI	UniProtKB:Q16543	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Limk2	IPI	PR:P53668	Mouse	PMID:16399995
Molecular Function	GO:0004672	protein kinase activity	Limk2	IMP	MGI:MGI:2180767	Mouse	PMID:11784110
Molecular Function	GO:0004674	protein serine/threonine kinase activity	LIMK2	IDA		Human	PMID:22328514
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Limk2	IDA		Rat	PMID:7651734|RGD:61653
Cellular Component	GO:0005813	centrosome	LIMK2	IDA		Human	PMID:25849865
Cellular Component	GO:0005801	cis-Golgi network	Limk2	IDA		Mouse	PMID:16399995
Cellular Component	GO:0005737	cytoplasm	Limk2	IDA		Mouse	PMID:16399995
Cellular Component	GO:0072686	mitotic spindle	LIMK2	IDA		Human	PMID:22328514
Cellular Component	GO:0005634	nucleus	Limk2	IDA		Mouse	PMID:16399995
Cellular Component	GO:0005634	nucleus	Limk2	IDA		Rat	PMID:9089416|RGD:1357215
Biological Process	GO:0030953	astral microtubule organization	LIMK2	IDA		Human	PMID:22328514
Biological Process	GO:0061303	cornea development in camera-type eye	Limk2	IMP	MGI:MGI:3612836	Mouse	PMID:26234751
Biological Process	GO:0051650	establishment of vesicle localization	LIMK2	IMP		Human	PMID:25849865
Biological Process	GO:0060322	head development	Limk2	IMP	MGI:MGI:3612836	Mouse	PMID:26234751
Biological Process	GO:1902018	negative regulation of cilium assembly	LIMK2	IMP		Human	PMID:25849865
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	LIMK2	IMP		Human	PMID:25849865
Biological Process	GO:0001934	positive regulation of protein phosphorylation	LIMK2	IMP		Human	PMID:25849865
Biological Process	GO:0006468	protein phosphorylation	LIMK2	IDA		Human	PMID:22328514
Biological Process	GO:0006468	protein phosphorylation	Limk2	IMP	MGI:MGI:2180767	Mouse	PMID:11784110
Biological Process	GO:0006468	protein phosphorylation	Limk2	IDA		Rat	PMID:7651734|RGD:61653
Biological Process	GO:0007283	spermatogenesis	Limk2	IMP	MGI:MGI:2180767	Mouse	PMID:11784110

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern