Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LETM1
  • Mouse genes Letm1
  • Rat genes Letm1
  • Zfish genes letm1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Letm1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015369	calcium:proton antiporter activity	LETM1	IDA		Human	PMID:19797662
Molecular Function	GO:0015369	calcium:proton antiporter activity	Letm1	IDA		Mouse	MGI:MGI:5897526|PMID:27669901
Molecular Function	GO:0015369	calcium:proton antiporter activity	Letm1	IMP		Mouse	MGI:MGI:5643854|PMID:23716663
Molecular Function	GO:0005515	protein binding	LETM1	IPI	UniProtKB:Q9Y276	Human	PMID:18628306
Molecular Function	GO:0005515	protein binding	LETM1	IPI	UniProtKB:P25788	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	LETM1	IPI	UniProtKB:P36508	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LETM1	IPI	UniProtKB:Q3LI66	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LETM1	IPI	UniProtKB:Q9H3K2	Human	PMID:36321428
Cellular Component	GO:0005743	mitochondrial inner membrane	LETM1	IDA		Human	PMID:18628306
Cellular Component	GO:0005743	mitochondrial inner membrane	LETM1	IDA		Human	PMID:19797662
Cellular Component	GO:0005743	mitochondrial inner membrane	LETM1	IDA		Human	PMID:32139798
Cellular Component	GO:0005743	mitochondrial inner membrane	Letm1	IDA		Mouse	MGI:MGI:5897526|PMID:27669901
Cellular Component	GO:0005743	mitochondrial inner membrane	Letm1	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005739	mitochondrion	LETM1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	Letm1	IDA		Mouse	MGI:MGI:2682130|PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Letm1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Letm1	HDA		Mouse	PMID:18614015
Biological Process	GO:0099093	calcium export from the mitochondrion	LETM1	IDA		Human	PMID:19797662
Biological Process	GO:0099093	calcium export from the mitochondrion	LETM1	IMP		Human	PMID:32139798
Biological Process	GO:0099093	calcium export from the mitochondrion	Letm1	IDA		Mouse	MGI:MGI:5897526|PMID:27669901
Biological Process	GO:0099093	calcium export from the mitochondrion	Letm1	IMP		Mouse	MGI:MGI:5643854|PMID:23716663
Biological Process	GO:0042407	cristae formation	LETM1	IMP		Human	PMID:18628306
Biological Process	GO:0007007	inner mitochondrial membrane organization	LETM1	IMP		Human	PMID:32139798
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	LETM1	IDA		Human	PMID:19797662
Biological Process	GO:0051560	mitochondrial calcium ion homeostasis	Letm1	IDA		Mouse	MGI:MGI:5897526|PMID:27669901
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	LETM1	IDA		Human	PMID:19797662
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	LETM1	IMP		Human	PMID:32139798
Biological Process	GO:0006851	mitochondrial calcium ion transmembrane transport	Letm1	IDA		Mouse	MGI:MGI:5897526|PMID:27669901
Biological Process	GO:0140141	mitochondrial potassium ion transmembrane transport	LETM1	IMP		Human	PMID:36055214
Biological Process	GO:0140141	mitochondrial potassium ion transmembrane transport	LETM1	IMP		Human	PMID:36321428
Biological Process	GO:0051562	negative regulation of mitochondrial calcium ion concentration	LETM1	IMP		Human	PMID:26975899
Biological Process	GO:0034214	protein hexamerization	Letm1	IDA		Mouse	MGI:MGI:5897526|PMID:27669901
Biological Process	GO:0051260	protein homooligomerization	Letm1	IDA		Mouse	MGI:MGI:5897526|PMID:27669901
Biological Process	GO:1900069	regulation of cellular hyperosmotic salinity response	LETM1	IMP		Human	PMID:26975899

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern