Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LEFTY1
  • Mouse genes Lefty1
  • Rat genes Lefty1
  • Zfish genes lft1,lft2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lefty1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0038100	nodal binding	Lefty1	IPI	UniProtKB:P43021	Mouse	MGI:MGI:3042530|PMID:15062104
Molecular Function	GO:0005515	protein binding	lft1	IPI	UniProtKB:P51865	Zfish	PMID:14966532|ZFIN:ZDB-PUB-200522-14
Cellular Component	GO:0005576	extracellular region	Lefty1	IDA		Mouse	MGI:MGI:3042530|PMID:15062104
Biological Process	GO:0009948	anterior/posterior axis specification	Lefty1	IGI	MGI:MGI:1201414	Mouse	PMID:15004567
Biological Process	GO:0042074	cell migration involved in gastrulation	Lefty1	IGI	MGI:MGI:1201414	Mouse	PMID:15004567
Biological Process	GO:0008283	cell population proliferation	Lefty1	IGI	MGI:MGI:1201414	Mouse	PMID:15004567
Biological Process	GO:0061371	determination of heart left/right asymmetry	lft1	IMP	ZFIN:ZDB-MRPHLNO-070410-5	Zfish	PMID:21980297
Biological Process	GO:0061371	determination of heart left/right asymmetry	lft1	IMP	ZFIN:ZDB-MRPHLNO-050119-6	Zfish	PMID:21937597
Biological Process	GO:0035462	determination of left/right asymmetry in diencephalon	lft1	IMP	ZFIN:ZDB-MRPHLNO-050119-6	Zfish	PMID:21937597
Biological Process	GO:0003140	determination of left/right asymmetry in lateral mesoderm	lft1	IMP	ZFIN:ZDB-MRPHLNO-050119-6	Zfish	PMID:21937597
Biological Process	GO:0007368	determination of left/right symmetry	Lefty1	IDA		Mouse	MGI:MGI:1277589|PMID:9708732
Biological Process	GO:0007368	determination of left/right symmetry	lft1	IMP	ZFIN:ZDB-MRPHLNO-050425-3	Zfish	PMID:18985756
Biological Process	GO:0009953	dorsal/ventral pattern formation	lft1	IDA		Zfish	PMID:10704853
Biological Process	GO:0035050	embryonic heart tube development	lft1	IMP		Zfish	PMID:15175246
Biological Process	GO:0003128	heart field specification	lft2	IMP	ZFIN:ZDB-MRPHLNO-050119-7	Zfish	PMID:21937597
Biological Process	GO:0003007	heart morphogenesis	Lefty1	IMP		Mouse	MGI:MGI:1277589|PMID:9708732
Biological Process	GO:0007498	mesoderm development	lft1	IMP	ZFIN:ZDB-GENO-180906-2	Zfish	PMID:29215332
Biological Process	GO:0007498	mesoderm development	lft2	IMP	ZFIN:ZDB-GENO-180906-2	Zfish	PMID:29215332
Biological Process	GO:0008285	negative regulation of cell population proliferation	Lefty1	IGI	MGI:MGI:1201414	Mouse	PMID:15004567
Biological Process	GO:1900124	negative regulation of nodal receptor complex assembly	Lefty1	IDA		Mouse	MGI:MGI:3042530|PMID:15062104
Biological Process	GO:1900108	negative regulation of nodal signaling pathway	Lefty1	IDA		Mouse	MGI:MGI:3042530|PMID:15062104
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Lefty1	IDA		Mouse	MGI:MGI:1277589|PMID:9708732
Biological Process	GO:0032526	response to retinoic acid	Lefty1	IDA		Mouse	PMID:10500184

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern