Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KLHL3
  • Mouse genes Klhl3
  • Rat genes Klhl3
  • Zfish genes klhl3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Klhl3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0097602	cullin family protein binding	KLHL3	IPI	UniProtKB:Q13618	Human	PMID:14528312
Molecular Function	GO:0005515	protein binding	KLHL3	IPI	UniProtKB:P55017	Human	PMID:22406640
Molecular Function	GO:0005515	protein binding	KLHL3	IPI	UniProtKB:Q96J92	Human	PMID:23453970
Molecular Function	GO:0005515	protein binding	KLHL3	IPI	UniProtKB:Q96J92	Human	PMID:23576762
Molecular Function	GO:0005515	protein binding	KLHL3	IPI	UniProtKB:Q13618	Human	PMID:23665031
Molecular Function	GO:0005515	protein binding	KLHL3	IPI	UniProtKB:Q13618	Human	PMID:25502805
Molecular Function	GO:0005515	protein binding	KLHL3	IPI	UniProtKB:Q13618	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	KLHL3	IPI	UniProtKB:O14787-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL3	IPI	UniProtKB:O95198	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL3	IPI	UniProtKB:Q13618	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL3	IPI	UniProtKB:Q14145	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL3	IPI	UniProtKB:Q53G59	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLHL3	IPI	UniProtKB:O14901	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLHL3	IPI	UniProtKB:O75190-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLHL3	IPI	UniProtKB:P01112	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLHL3	IPI	UniProtKB:P06396	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLHL3	IPI	UniProtKB:P13473-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLHL3	IPI	UniProtKB:P22607	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	KLHL3	IPI	UniProtKB:P55212	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Klhl3	IPI	UniProtKB:Q80UE6	Mouse	PMID:25313067
Molecular Function	GO:0005515	protein binding	Klhl3	IPI	UniProtKB:Q80UE6	Mouse	PMID:23576762
Molecular Function	GO:0005515	protein binding	Klhl3	IPI	UniProtKB:Q80UE6	Mouse	PMID:24821705
Molecular Function	GO:0005515	protein binding	Klhl3	IPI	UniProtKB:Q9JLV5	Mouse	PMID:25250572
Molecular Function	GO:0005515	protein binding	Klhl3	IPI	UniProtKB:P83741	Mouse	PMID:23576762
Molecular Function	GO:0005515	protein binding	Klhl3	IPI	UniProtKB:P83741	Mouse	PMID:24821705
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	KLHL3	IDA		Human	PMID:23453970
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex	KLHL3	IDA		Human	PMID:23576762
Cellular Component	GO:0005829	cytosol	KLHL3	IDA		Human	PMID:22406640
Biological Process	GO:0072156	distal tubule morphogenesis	KLHL3	IMP		Human	PMID:22406640
Biological Process	GO:0072156	distal tubule morphogenesis	KLHL3	IMP		Human	PMID:23453970
Biological Process	GO:0072156	distal tubule morphogenesis	KLHL3	IMP		Human	PMID:23576762
Biological Process	GO:0010467	gene expression	Klhl3	IMP		Mouse	PMID:23576762
Biological Process	GO:0010467	gene expression	Klhl3	IGI	MGI:MGI:1917097	Mouse	PMID:28743496
Biological Process	GO:0010467	gene expression	Klhl3	IMP	MGI:MGI:5646378	Mouse	PMID:24821705
Biological Process	GO:0010467	gene expression	Klhl3	IDA	MGI:MGI:1917097	Mouse	PMID:23576762
Biological Process	GO:0008152	metabolic process	Klhl3	IMP	MGI:MGI:5646378	Mouse	PMID:24821705
Biological Process	GO:0050801	monoatomic ion homeostasis	KLHL3	IMP		Human	PMID:23453970
Biological Process	GO:0050801	monoatomic ion homeostasis	KLHL3	IMP		Human	PMID:23576762
Biological Process	GO:0050801	monoatomic ion homeostasis	Klhl3	IMP		Mouse	PMID:23576762
Biological Process	GO:0055075	potassium ion homeostasis	Klhl3	IMP	MGI:MGI:5646378	Mouse	PMID:24821705
Biological Process	GO:0030163	protein catabolic process	Klhl3	IMP		Mouse	PMID:23576762
Biological Process	GO:0030163	protein catabolic process	Klhl3	IMP		Mouse	PMID:25313067
Biological Process	GO:0070936	protein K48-linked ubiquitination	KLHL3	IDA		Human	PMID:23576762
Biological Process	GO:0006468	protein phosphorylation	Klhl3	IMP	MGI:MGI:5646378	Mouse	PMID:24821705
Biological Process	GO:0006468	protein phosphorylation	Klhl3	IGI	MGI:MGI:1917097	Mouse	PMID:28743496
Biological Process	GO:0000209	protein polyubiquitination	Klhl3	IDA	MGI:MGI:1917097	Mouse	PMID:23576762
Biological Process	GO:0000209	protein polyubiquitination	Klhl3	IMP		Mouse	PMID:23576762
Biological Process	GO:0016567	protein ubiquitination	KLHL3	IDA		Human	PMID:23453970
Biological Process	GO:0070293	renal absorption	Klhl3	IMP	MGI:MGI:5646378	Mouse	PMID:24821705
Biological Process	GO:0070294	renal sodium ion absorption	KLHL3	IMP		Human	PMID:22406640
Biological Process	GO:0070294	renal sodium ion absorption	KLHL3	IMP		Human	PMID:23453970
Biological Process	GO:0070294	renal sodium ion absorption	KLHL3	IMP		Human	PMID:23576762
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	KLHL3	IDA		Human	PMID:23453970
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	KLHL3	IDA		Human	PMID:23576762

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern